Meta-analyses of associations between interleukin-10 polymorphisms and susceptibility to recurrent pregnancy loss
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Kim, Jae-Hoon | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-04T00:04:06Z | - |
dc.date.available | 2021-09-04T00:04:06Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-05 | - |
dc.identifier.issn | 0301-2115 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88733 | - |
dc.description.abstract | Objective: The aim of this study was to investigate whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to recurrent pregnancy loss (RPL). Methods: We conducted a literature search using the PubMed and EMBASE databases and performed meta-analyses on the associations between IL-10 -1082 G/A, -819 C/T, and -592 C/A polymorphisms and RPL, using fixed-or random-effects models. Results: A total of 15 papers involving 1858 RPL patients and 1949 controls were considered in this study. Meta-analysis of IL-10 -1082 G/A polymorphism revealed no association between RPL and the IL-10 -1082 G allele (OR = 0.999, 95% CI = 0.815-1.223, p = 0.989). However, meta-analysis of IL-10 -819 C/T polymorphism in all study subjects revealed an association between RPL and the IL-10 -819 C allele (OR = 0.680, 95% CI = 0.498-0.927, p = 0.015). Stratification by ethnicity indicated an association between the IL-10 -819 C allele and RPL in the Asian group (OR = 0.421, 95% CI = 0.226-0.783,p = 0.006), but not in the Caucasian and Arab groups (OR = 1.053, 95% CI = 0.218-5.077, p = 0.949, and OR = 0.800, 95% CI = 0.606-1.081, p = 0.152, respectively). Furthermore, a relationship between the IL-10 -592 C allele and RPL was identified in the Asian group (OR = 0.763, 95% CI = 0.633-0.919, p = 0.004), but not in the Caucasian and Arab groups. Conclusions: The meta-analyses demonstrate that IL-10 -819 C/T and -592 C/A polymorphisms are associated with RPL susceptibility in Asian women, but not in the Caucasian and Arab populations. (C) 2016 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | CYTOKINE GENE POLYMORPHISMS | - |
dc.subject | SPONTANEOUS-ABORTIONS | - |
dc.subject | PROMOTER POLYMORPHISM | - |
dc.subject | IL-10 | - |
dc.subject | WOMEN | - |
dc.subject | MISCARRIAGE | - |
dc.subject | EXPRESSION | - |
dc.subject | RECEPTOR | - |
dc.subject | TRIAD | - |
dc.subject | RISK | - |
dc.title | Meta-analyses of associations between interleukin-10 polymorphisms and susceptibility to recurrent pregnancy loss | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1016/j.ejogrb.2016.02.032 | - |
dc.identifier.scopusid | 2-s2.0-84960087898 | - |
dc.identifier.wosid | 000385991800010 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, v.200, pp.51 - 57 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | - |
dc.citation.title | EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | - |
dc.citation.volume | 200 | - |
dc.citation.startPage | 51 | - |
dc.citation.endPage | 57 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalResearchArea | Reproductive Biology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Reproductive Biology | - |
dc.subject.keywordPlus | CYTOKINE GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | SPONTANEOUS-ABORTIONS | - |
dc.subject.keywordPlus | PROMOTER POLYMORPHISM | - |
dc.subject.keywordPlus | IL-10 | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | MISCARRIAGE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | TRIAD | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | RPL | - |
dc.subject.keywordAuthor | Interleukin-10 | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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