Meta-analyses of associations between interleukin-10 polymorphisms and susceptibility to recurrent pregnancy loss
- Authors
- Lee, Young Ho; Kim, Jae-Hoon; Song, Gwan Gyu
- Issue Date
- 5월-2016
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- RPL; Interleukin-10; Polymorphism; Meta-analysis
- Citation
- EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, v.200, pp.51 - 57
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
- Volume
- 200
- Start Page
- 51
- End Page
- 57
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/88733
- DOI
- 10.1016/j.ejogrb.2016.02.032
- ISSN
- 0301-2115
- Abstract
- Objective: The aim of this study was to investigate whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to recurrent pregnancy loss (RPL). Methods: We conducted a literature search using the PubMed and EMBASE databases and performed meta-analyses on the associations between IL-10 -1082 G/A, -819 C/T, and -592 C/A polymorphisms and RPL, using fixed-or random-effects models. Results: A total of 15 papers involving 1858 RPL patients and 1949 controls were considered in this study. Meta-analysis of IL-10 -1082 G/A polymorphism revealed no association between RPL and the IL-10 -1082 G allele (OR = 0.999, 95% CI = 0.815-1.223, p = 0.989). However, meta-analysis of IL-10 -819 C/T polymorphism in all study subjects revealed an association between RPL and the IL-10 -819 C allele (OR = 0.680, 95% CI = 0.498-0.927, p = 0.015). Stratification by ethnicity indicated an association between the IL-10 -819 C allele and RPL in the Asian group (OR = 0.421, 95% CI = 0.226-0.783,p = 0.006), but not in the Caucasian and Arab groups (OR = 1.053, 95% CI = 0.218-5.077, p = 0.949, and OR = 0.800, 95% CI = 0.606-1.081, p = 0.152, respectively). Furthermore, a relationship between the IL-10 -592 C allele and RPL was identified in the Asian group (OR = 0.763, 95% CI = 0.633-0.919, p = 0.004), but not in the Caucasian and Arab groups. Conclusions: The meta-analyses demonstrate that IL-10 -819 C/T and -592 C/A polymorphisms are associated with RPL susceptibility in Asian women, but not in the Caucasian and Arab populations. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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