New Alkyl Phloroglucinol Derivatives from Rhus trichocarpa Roots and Their Cytotoxic Effects on Human Gastric Adenocarcinoma AGS Cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Ki Yong | - |
dc.contributor.author | Choi, Ji Hoon | - |
dc.contributor.author | Kim, HyeonWoo | - |
dc.contributor.author | Yan, Xi-Tao | - |
dc.contributor.author | Shin, Hyeji | - |
dc.contributor.author | Jeon, Young Ho | - |
dc.contributor.author | Sung, Sang Hyun | - |
dc.date.accessioned | 2021-09-04T00:14:15Z | - |
dc.date.available | 2021-09-04T00:14:15Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-05 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88810 | - |
dc.description.abstract | The phytochemical investigation of the roots of Rhus trichocarpa led to this isolation of five new alkyl phloroglucinol derivatives, characterized as (Z)-15-hydroxy-1-(2,4,6-trihydroxyphenyl)-9-octadecen-1-one (named trichocarpol A, 1), (Z)-15-hydroxy-1-(2,6-dihydroxy-4-methoxyphenyl)-9-octadecen-1-one (named trichocarpol B, 2), (Z)-17-hydroxy-1-(2,4,6-trihydroxyphenyl)-9-octadecen-1-one (named trichocarpol C, 3), (Z)-18-hydroxy-1-(2,4,6-trihydroxyphenyl)-9-octadecen-1-one (named trichocarpol D, 4), and (9Z,12Z)-18-hydroxy-1-(2,4,6-trihydroxyphenyl)-9,12-octadecadien-1-one (named trichocarpol E, 5), together with a known compound, 4-(2,6-dihydroxy-4-methoxyphenyl)-4-oxobutanoic acid (6). In vitro cytotoxic activity of compounds 1-6 was evaluated in the human gastric adenocarcinoma AGS cell line and compounds 1-5 showed significant cytotoxicity. Our results indicate that R.trichocarpa, especially the alkyl phloroglucinol derivatives in it, is a good source of promising natural agents for the treatment of gastric cancer. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | GEORG THIEME VERLAG KG | - |
dc.title | New Alkyl Phloroglucinol Derivatives from Rhus trichocarpa Roots and Their Cytotoxic Effects on Human Gastric Adenocarcinoma AGS Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Ki Yong | - |
dc.contributor.affiliatedAuthor | Jeon, Young Ho | - |
dc.identifier.doi | 10.1055/s-0035-1568276 | - |
dc.identifier.scopusid | 2-s2.0-84957607139 | - |
dc.identifier.wosid | 000376082000008 | - |
dc.identifier.bibliographicCitation | PLANTA MEDICA, v.82, no.7, pp.645 - 649 | - |
dc.relation.isPartOf | PLANTA MEDICA | - |
dc.citation.title | PLANTA MEDICA | - |
dc.citation.volume | 82 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 645 | - |
dc.citation.endPage | 649 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordAuthor | Rhus trichocarpa | - |
dc.subject.keywordAuthor | Anacardiaceae | - |
dc.subject.keywordAuthor | alkyl phloroglucinols | - |
dc.subject.keywordAuthor | cytotoxicity | - |
dc.subject.keywordAuthor | AGS cells | - |
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