New Alkyl Phloroglucinol Derivatives from Rhus trichocarpa Roots and Their Cytotoxic Effects on Human Gastric Adenocarcinoma AGS Cells
- Authors
- Lee, Ki Yong; Choi, Ji Hoon; Kim, HyeonWoo; Yan, Xi-Tao; Shin, Hyeji; Jeon, Young Ho; Sung, Sang Hyun
- Issue Date
- 5월-2016
- Publisher
- GEORG THIEME VERLAG KG
- Keywords
- Rhus trichocarpa; Anacardiaceae; alkyl phloroglucinols; cytotoxicity; AGS cells
- Citation
- PLANTA MEDICA, v.82, no.7, pp.645 - 649
- Indexed
- SCIE
SCOPUS
- Journal Title
- PLANTA MEDICA
- Volume
- 82
- Number
- 7
- Start Page
- 645
- End Page
- 649
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/88810
- DOI
- 10.1055/s-0035-1568276
- ISSN
- 0032-0943
- Abstract
- The phytochemical investigation of the roots of Rhus trichocarpa led to this isolation of five new alkyl phloroglucinol derivatives, characterized as (Z)-15-hydroxy-1-(2,4,6-trihydroxyphenyl)-9-octadecen-1-one (named trichocarpol A, 1), (Z)-15-hydroxy-1-(2,6-dihydroxy-4-methoxyphenyl)-9-octadecen-1-one (named trichocarpol B, 2), (Z)-17-hydroxy-1-(2,4,6-trihydroxyphenyl)-9-octadecen-1-one (named trichocarpol C, 3), (Z)-18-hydroxy-1-(2,4,6-trihydroxyphenyl)-9-octadecen-1-one (named trichocarpol D, 4), and (9Z,12Z)-18-hydroxy-1-(2,4,6-trihydroxyphenyl)-9,12-octadecadien-1-one (named trichocarpol E, 5), together with a known compound, 4-(2,6-dihydroxy-4-methoxyphenyl)-4-oxobutanoic acid (6). In vitro cytotoxic activity of compounds 1-6 was evaluated in the human gastric adenocarcinoma AGS cell line and compounds 1-5 showed significant cytotoxicity. Our results indicate that R.trichocarpa, especially the alkyl phloroglucinol derivatives in it, is a good source of promising natural agents for the treatment of gastric cancer.
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Collections - College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
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