Doxorubicin/gold-loaded core/shell nanoparticles for combination therapy to treat cancer through the enhanced tumor targeting
DC Field | Value | Language |
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dc.contributor.author | Kim, Kyungim | - |
dc.contributor.author | Oh, Keun Sang | - |
dc.contributor.author | Park, Dal Yong | - |
dc.contributor.author | Lee, Jae Young | - |
dc.contributor.author | Lee, Beom Suk | - |
dc.contributor.author | Kim, In San | - |
dc.contributor.author | Kim, Kwangmeyung | - |
dc.contributor.author | Kwon, Ick Chan | - |
dc.contributor.author | Kim, SangYoon | - |
dc.contributor.author | Yuk, Soon Hong | - |
dc.date.accessioned | 2021-09-04T00:24:17Z | - |
dc.date.available | 2021-09-04T00:24:17Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-04-28 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88887 | - |
dc.description.abstract | A combination therapy consisting of radiotherapy and chemotherapy is performed using the core/shell nanoparticles (NPs) containing gold NPs and doxorubicin (DOX). Gold NPs in the core/shell NPs were utilized as a radiosensitizer. To examine the morphology and size distribution of the core/shell NPs, transmittance electron microscopy and dynamic light scattering were used. The in vitro release behavior, cellular uptake and toxicity were also observed to verify the functionality of the core/shell NPs as a nanocarrier. To demonstrate the advantage of the core/shell NPs over traditional gold NPs reported in the combination therapy, we evaluated the accumulation behavior of the core/shell NPs at the tumor site using the biodistribution. Antitumor efficacy was observed with and without radiation to evaluate the role of gold NPs as a radiosensitizer. (C) 2016 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | INVASIVE BLADDER-CANCER | - |
dc.subject | OXIDE) TRIBLOCK COPOLYMERS | - |
dc.subject | COATED GOLD NANOPARTICLES | - |
dc.subject | RADIATION-THERAPY | - |
dc.subject | VESICLE FUSION | - |
dc.subject | BREAST-CANCER | - |
dc.subject | LUNG-CANCER | - |
dc.subject | RADIOTHERAPY | - |
dc.subject | DELIVERY | - |
dc.subject | MICELLES | - |
dc.title | Doxorubicin/gold-loaded core/shell nanoparticles for combination therapy to treat cancer through the enhanced tumor targeting | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Kyungim | - |
dc.contributor.affiliatedAuthor | Kim, In San | - |
dc.contributor.affiliatedAuthor | Yuk, Soon Hong | - |
dc.identifier.doi | 10.1016/j.jconrel.2016.03.009 | - |
dc.identifier.scopusid | 2-s2.0-84960931563 | - |
dc.identifier.wosid | 000373429600015 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CONTROLLED RELEASE, v.228, pp.141 - 149 | - |
dc.relation.isPartOf | JOURNAL OF CONTROLLED RELEASE | - |
dc.citation.title | JOURNAL OF CONTROLLED RELEASE | - |
dc.citation.volume | 228 | - |
dc.citation.startPage | 141 | - |
dc.citation.endPage | 149 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | INVASIVE BLADDER-CANCER | - |
dc.subject.keywordPlus | OXIDE) TRIBLOCK COPOLYMERS | - |
dc.subject.keywordPlus | COATED GOLD NANOPARTICLES | - |
dc.subject.keywordPlus | RADIATION-THERAPY | - |
dc.subject.keywordPlus | VESICLE FUSION | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | MICELLES | - |
dc.subject.keywordAuthor | Combination therapy | - |
dc.subject.keywordAuthor | Radiotherapy | - |
dc.subject.keywordAuthor | Core/shell nanoparticles | - |
dc.subject.keywordAuthor | Gold nanoparticles | - |
dc.subject.keywordAuthor | Doxorubicin | - |
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