Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Doxorubicin/gold-loaded core/shell nanoparticles for combination therapy to treat cancer through the enhanced tumor targeting
- Authors
- Kim, Kyungim; Oh, Keun Sang; Park, Dal Yong; Lee, Jae Young; Lee, Beom Suk; Kim, In San; Kim, Kwangmeyung; Kwon, Ick Chan; Kim, SangYoon; Yuk, Soon Hong
- Issue Date
- 28-4월-2016
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Combination therapy; Radiotherapy; Core/shell nanoparticles; Gold nanoparticles; Doxorubicin
- Citation
- JOURNAL OF CONTROLLED RELEASE, v.228, pp.141 - 149
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CONTROLLED RELEASE
- Volume
- 228
- Start Page
- 141
- End Page
- 149
- ISSN
- 0168-3659
- Abstract
- A combination therapy consisting of radiotherapy and chemotherapy is performed using the core/shell nanoparticles (NPs) containing gold NPs and doxorubicin (DOX). Gold NPs in the core/shell NPs were utilized as a radiosensitizer. To examine the morphology and size distribution of the core/shell NPs, transmittance electron microscopy and dynamic light scattering were used. The in vitro release behavior, cellular uptake and toxicity were also observed to verify the functionality of the core/shell NPs as a nanocarrier. To demonstrate the advantage of the core/shell NPs over traditional gold NPs reported in the combination therapy, we evaluated the accumulation behavior of the core/shell NPs at the tumor site using the biodistribution. Antitumor efficacy was observed with and without radiation to evaluate the role of gold NPs as a radiosensitizer. (C) 2016 Elsevier B.V. All rights reserved.
- Files in This Item
- There are no files associated with this item.
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.