Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Association between Snoring and Leukocyte Telomere Length

Authors
Shin, CholYun, Chang-HoYoon, Dae WuiBaik, Inkyung
Issue Date
1-4월-2016
Publisher
OXFORD UNIV PRESS INC
Keywords
population-based study; leukocyte telomere length; polysomnography; snoring
Citation
SLEEP, v.39, no.4, pp.767 - 772
Indexed
SCIE
SCOPUS
Journal Title
SLEEP
Volume
39
Number
4
Start Page
767
End Page
772
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/88946
DOI
10.5665/sleep.5624
ISSN
0161-8105
Abstract
Study Objectives: Data on the association between snoring and telomere length, an indicator of biological aging, are very limited. Moreover, no polysomnography (PSG) studies on this association in a general population have been conducted. Our study aimed to evaluate the association between snoring and leukocyte telomere length (LTL) using PSG and a questionnaire. Methods: A cross-sectional PSG study embedded in a population-based cohort from the Korean Genome Epidemiology Study was conducted in 2010-2013. During the same period, questionnaire-based interviews, blood collection, and relative LTL assays were conducted. A total of 887 Korean men and women aged 50-79 y with an apnea-hypopnea index (AHI) < 15 determined in the PSG study were included in the study. Results: We observed that the percentage of time spent snoring during sleep (% time spent snoring) assessed by PSG was inversely associated with LTL even after adjusting for potential risk factors and AHI. In the linear regression association between tertiles of percentage of time spent snoring and log-transformed LTL, coefficient estimates (P value) were -0.076 (< 0.05) for the second tertile and -0.084 (< 0.01) for the third tertile compared with the bottom tertile. When LTL was compared according to snoring status determined using PSG and questionnaire information, both primary snorers and those with mild sleep apnea (5 <= AHI < 15) had shorter LTL than nonsnorers. Conclusions: Our findings suggest that snoring may influence telomere attrition independent of sleep apnea.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE