Caveolin-1 Modulates Docetaxel-Induced Cell Death in Breast Cancer Cell Subtypes through Different Mechanisms
DC Field | Value | Language |
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dc.contributor.author | Kang, Jinho | - |
dc.contributor.author | Park, Joo Hee | - |
dc.contributor.author | Lee, Hye Jin | - |
dc.contributor.author | Jo, Ukhyun | - |
dc.contributor.author | Park, Jong Kuk | - |
dc.contributor.author | Seo, Jae Hong | - |
dc.contributor.author | Kim, Yeul Hong | - |
dc.contributor.author | Kim, Insun | - |
dc.contributor.author | Park, Kyong Hwa | - |
dc.date.accessioned | 2021-09-04T00:51:36Z | - |
dc.date.available | 2021-09-04T00:51:36Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88970 | - |
dc.description.abstract | Purpose Caveolin-1 (CAV-1) expression is more associated with basal-like cancers than estrogen receptor- or ErbB-2-expressing breast cancers. However, the biological relevance of different levels of CAV-1 expression according to subtype in the epithelial compartment of breast cancer remains unclear. Materials and Methods We investigated whether CAV-1 functions as a tumor suppressor and/or modulator of the cytotoxic activity of docetaxel (DTX) in subtypes of breast cancer using in vitro and xenograft models. Results The levels of CAV-1 expression were closely associated with DTX sensitivity in triple-negative breast cancer cells. In addition, CAV-1 significantly inhibited cell proliferation and modulated DTX-induced apoptosis through cell cycle arrest in the G2/M phase. The mechanisms underlying DTX-induced apoptosis differed in breast cancers according to the levels of CAV1 expression. DTX robustly enhanced Bcl-2 inactivation by CAV-1 in MDA-MB-231 cells, while p53-mediated cell cycle arrest by DD( was more pronounced in CAV-1-low but p53-functional MCF-7 cells. In parallel with the data from breast cancer cell lines, CAV-1-transfected MCF-7 cells showed higher efficacy of DTX treatment in a xenograft model. Conclusion We clearly demonstrated cooperative effects between CAV-1 and DTX in mediating apoptosis, suggesting that the levels of CAV-1 expression might be an important indicator for DTX use in breast cancer. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN CANCER ASSOCIATION | - |
dc.subject | POOR-PROGNOSIS | - |
dc.subject | UP-REGULATION | - |
dc.subject | IN-SITU | - |
dc.subject | EXPRESSION | - |
dc.subject | PACLITAXEL | - |
dc.subject | CARCINOMA | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | OVEREXPRESSION | - |
dc.subject | CHEMOTHERAPY | - |
dc.subject | PROGRESSION | - |
dc.title | Caveolin-1 Modulates Docetaxel-Induced Cell Death in Breast Cancer Cell Subtypes through Different Mechanisms | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Seo, Jae Hong | - |
dc.contributor.affiliatedAuthor | Kim, Yeul Hong | - |
dc.contributor.affiliatedAuthor | Kim, Insun | - |
dc.contributor.affiliatedAuthor | Park, Kyong Hwa | - |
dc.identifier.doi | 10.4143/crt.2015.227 | - |
dc.identifier.scopusid | 2-s2.0-84963836252 | - |
dc.identifier.wosid | 000374197200033 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, v.48, no.2, pp.715 - 726 | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.citation.title | CANCER RESEARCH AND TREATMENT | - |
dc.citation.volume | 48 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 715 | - |
dc.citation.endPage | 726 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002099277 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | POOR-PROGNOSIS | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | IN-SITU | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordAuthor | Caveolin 1 | - |
dc.subject.keywordAuthor | Breast neoplasms | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Docetaxel | - |
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