Caveolin-1 Modulates Docetaxel-Induced Cell Death in Breast Cancer Cell Subtypes through Different Mechanisms
- Authors
- Kang, Jinho; Park, Joo Hee; Lee, Hye Jin; Jo, Ukhyun; Park, Jong Kuk; Seo, Jae Hong; Kim, Yeul Hong; Kim, Insun; Park, Kyong Hwa
- Issue Date
- 4월-2016
- Publisher
- KOREAN CANCER ASSOCIATION
- Keywords
- Caveolin 1; Breast neoplasms; Apoptosis; Docetaxel
- Citation
- CANCER RESEARCH AND TREATMENT, v.48, no.2, pp.715 - 726
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- CANCER RESEARCH AND TREATMENT
- Volume
- 48
- Number
- 2
- Start Page
- 715
- End Page
- 726
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/88970
- DOI
- 10.4143/crt.2015.227
- ISSN
- 1598-2998
- Abstract
- Purpose Caveolin-1 (CAV-1) expression is more associated with basal-like cancers than estrogen receptor- or ErbB-2-expressing breast cancers. However, the biological relevance of different levels of CAV-1 expression according to subtype in the epithelial compartment of breast cancer remains unclear. Materials and Methods We investigated whether CAV-1 functions as a tumor suppressor and/or modulator of the cytotoxic activity of docetaxel (DTX) in subtypes of breast cancer using in vitro and xenograft models. Results The levels of CAV-1 expression were closely associated with DTX sensitivity in triple-negative breast cancer cells. In addition, CAV-1 significantly inhibited cell proliferation and modulated DTX-induced apoptosis through cell cycle arrest in the G2/M phase. The mechanisms underlying DTX-induced apoptosis differed in breast cancers according to the levels of CAV1 expression. DTX robustly enhanced Bcl-2 inactivation by CAV-1 in MDA-MB-231 cells, while p53-mediated cell cycle arrest by DD( was more pronounced in CAV-1-low but p53-functional MCF-7 cells. In parallel with the data from breast cancer cell lines, CAV-1-transfected MCF-7 cells showed higher efficacy of DTX treatment in a xenograft model. Conclusion We clearly demonstrated cooperative effects between CAV-1 and DTX in mediating apoptosis, suggesting that the levels of CAV-1 expression might be an important indicator for DTX use in breast cancer.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
- College of Medicine > Department of Medical Science > 1. Journal Articles
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