Germinated Waxy Black Rice Suppresses Weight Gain in High-Fat Diet-Induced Obese Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Won-Chul | - |
dc.contributor.author | Ho, Jin-Nyoung | - |
dc.contributor.author | Lee, Hee-Seop | - |
dc.contributor.author | Cho, Hong-Yon | - |
dc.date.accessioned | 2021-09-04T00:53:47Z | - |
dc.date.available | 2021-09-04T00:53:47Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 1096-620X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88985 | - |
dc.description.abstract | This study was performed to investigate the antiobesity effect of germinated waxy black rice (GWBR) in high-fat diet (HFD)-induced obese mice. The mice were divided into a normal diet (ND) group, HFD group, and 2 test groups for 8 weeks: 2.5% GWBR-supplemented (GWBR-2.5) group and 5% GWBR-supplemented (GWBR-5) group. Supplementing with GWBR significantly reduced body weight gain and lipid accumulation in the liver and adipose tissue compared to the HFD control group. Triglyceride (TG), total cholesterol, and low-density lipoprotein-cholesterol levels in serum were decreased by GWBR supplementation, whereas high-density lipoprotein-cholesterol level significantly increased. In addition, mRNA levels of transcriptional factors, such as peroxisome proliferator-activated receptor-, CCAAT enhancer-binding protein (C/EBP)-, C/EBP-, sterol regulatory element-binding protein-1c, and related genes, including adipocyte fatty acid-binding protein, fatty acid synthase, and lipoprotein lipase, were significantly lower in the GWBR groups. However, lipolytic enzymes, such as hormone-sensitive lipase, adipose TG lipase, and carnitine palmitoyltransferase-1, and uncoupling protein 2 mRNA levels were significantly higher in GWBR-supplemented mice. These results suggest that GWBR exerts antiobesity effects by decreasing lipid accumulation and promoting lipolysis in HFD-induced obese mice. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.subject | CELL-PROLIFERATION | - |
dc.subject | 3T3-L1 ADIPOCYTES | - |
dc.subject | DOWN-REGULATION | - |
dc.subject | ADIPOSE-TISSUE | - |
dc.subject | C57BL/6J MICE | - |
dc.subject | BROWN RICE | - |
dc.subject | EXTRACT | - |
dc.subject | EXPRESSION | - |
dc.subject | LIPOLYSIS | - |
dc.subject | GENES | - |
dc.title | Germinated Waxy Black Rice Suppresses Weight Gain in High-Fat Diet-Induced Obese Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Hong-Yon | - |
dc.identifier.doi | 10.1089/jmf.2015.3590 | - |
dc.identifier.scopusid | 2-s2.0-84964570053 | - |
dc.identifier.wosid | 000374648400010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICINAL FOOD, v.19, no.4, pp.410 - 417 | - |
dc.relation.isPartOf | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.title | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.volume | 19 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 410 | - |
dc.citation.endPage | 417 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002101218 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | CELL-PROLIFERATION | - |
dc.subject.keywordPlus | 3T3-L1 ADIPOCYTES | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | C57BL/6J MICE | - |
dc.subject.keywordPlus | BROWN RICE | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | LIPOLYSIS | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordAuthor | antiobesity | - |
dc.subject.keywordAuthor | germinated waxy black rice | - |
dc.subject.keywordAuthor | high-fat diet-induced obese mice | - |
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