Evaluation of Prebiotic Effects of High-Purity Galactooligosaccharides in vitro and in vivo
DC Field | Value | Language |
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dc.contributor.author | Hong, Ki Bae | - |
dc.contributor.author | Kim, Jae Hwan | - |
dc.contributor.author | Kwon, Hyuk Kon | - |
dc.contributor.author | Han, Sung Hee | - |
dc.contributor.author | Park, Yooheon | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.date.accessioned | 2021-09-04T01:01:53Z | - |
dc.date.available | 2021-09-04T01:01:53Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 1330-9862 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89045 | - |
dc.description.abstract | Galactooligosaccharides (GOS) are an important class of dietary prebiotics that exert beneficial effects on intestinal microbiota and gut barrier function. In this study, high-purity GOS (HP-GOS) were investigated in vitro and in vivo and confirmed as prebiotic ingredients in rat diet. HP-GOS were successfully produced using a two-step process, enzymatic hydrolysis and fermentation by yeast. They were found to serve as a good substrate and carbon source for supporting the growth of probiotic bacteria more effectively than other commercial GOS. Following administration of 1 % (by mass) of HP-GOS to rats, the growth of Bifidobacterium bifidum and B. longum in the gut increased most rapidly up to 12 h, and thereafter the increase was slow. Therefore, 1 % HP-GOS was found to be acceptable for the growth of probiotic bacteria. Groups of animals that were orally administered HP-GOS and bifidobacteria during the study, and the group administered HP-GOS during the 2nd (days 13-15) and 4th (days 28-30) period of the study had significantly (p<0.05) higher numbers of bifidobacteria in faeces than groups receiving a single dose of bifidobacteria. HP-GOS affected the expression of genes encoding glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). There was a significant upregulation of GLP-1 and PYY mRNA with HP-GOS and bifidobacteria intake. We propose that the prebiotic properties of HP-GOS are potentially valuable for the production of functional foods for human consumption. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | FACULTY FOOD TECHNOLOGY BIOTECHNOLOGY | - |
dc.subject | BETA-GALACTOOLIGOSACCHARIDES | - |
dc.subject | BIFIDOBACTERIUM-LONGUM | - |
dc.subject | SATIETY HORMONES | - |
dc.subject | ENZYME CATALYSIS | - |
dc.subject | GUT PEPTIDES | - |
dc.subject | OLIGOSACCHARIDES | - |
dc.subject | LACTOBACILLUS | - |
dc.subject | GROWTH | - |
dc.subject | DIETS | - |
dc.subject | RATS | - |
dc.title | Evaluation of Prebiotic Effects of High-Purity Galactooligosaccharides in vitro and in vivo | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.17113/ftb.54.02.16.4292 | - |
dc.identifier.scopusid | 2-s2.0-84988932352 | - |
dc.identifier.wosid | 000383356000004 | - |
dc.identifier.bibliographicCitation | FOOD TECHNOLOGY AND BIOTECHNOLOGY, v.54, no.2, pp.156 - 163 | - |
dc.relation.isPartOf | FOOD TECHNOLOGY AND BIOTECHNOLOGY | - |
dc.citation.title | FOOD TECHNOLOGY AND BIOTECHNOLOGY | - |
dc.citation.volume | 54 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 156 | - |
dc.citation.endPage | 163 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | BETA-GALACTOOLIGOSACCHARIDES | - |
dc.subject.keywordPlus | BIFIDOBACTERIUM-LONGUM | - |
dc.subject.keywordPlus | SATIETY HORMONES | - |
dc.subject.keywordPlus | ENZYME CATALYSIS | - |
dc.subject.keywordPlus | GUT PEPTIDES | - |
dc.subject.keywordPlus | OLIGOSACCHARIDES | - |
dc.subject.keywordPlus | LACTOBACILLUS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | DIETS | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordAuthor | high-purity galactooligosaccharides | - |
dc.subject.keywordAuthor | bifidobacteria | - |
dc.subject.keywordAuthor | genes encoding GLP-1 and PYY peptides | - |
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