Strong and Biostable Hyaluronic Acid-Calcium Phosphate Nanocomposite Hydrogel via in Situ Precipitation Process
DC Field | Value | Language |
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dc.contributor.author | Jeong, Seol-Ha | - |
dc.contributor.author | Koh, Young-Hag | - |
dc.contributor.author | Kim, Suk-Wha | - |
dc.contributor.author | Park, Ji-Ung | - |
dc.contributor.author | Kim, Hyoun-Ee | - |
dc.contributor.author | Song, Juha | - |
dc.date.accessioned | 2021-09-04T02:07:08Z | - |
dc.date.available | 2021-09-04T02:07:08Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-03 | - |
dc.identifier.issn | 1525-7797 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89336 | - |
dc.description.abstract | Hyaluronic acid (HAc) hydrogel exhibits excellent biocompatibility, but it has limited biomedical application due to its poor biomechanical properties as well as too-fast enzymatic degradation. In this study, we have developed an in situ precipitation process for the fabrication of a HAc-calcium phosphate nanocomposite hydrogel, after the formation of the glycidyl methacrylate-conjugated HAc (GMHA) hydrogels via photo-cross-linking, to improve the mechanical and biological properties under physiological conditions. In particular, our process facilitates the rapid incorporation of calcium phosphate (CaP) nanoparticles of uniform size and with minimal agglomeration into a polymer matrix, homogeneously. Compared with pure HAc, the nanocomposite hydrogels exhibit improved mechanical behavior. Specifically, the shear modulus is improved by a factor of 4. The biostability of the nanocomposite hydrogel was also significantly improved compared with that of pure HAc hydrogels tinder both in vitro and in vivo conditions. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | SIMPLE SURFACE MODIFICATION | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | BIODEGRADABLE HYDROGELS | - |
dc.subject | CROSS-LINKING | - |
dc.subject | APATITE | - |
dc.subject | COMPOSITE | - |
dc.subject | CHITOSAN | - |
dc.subject | COLLAGEN | - |
dc.subject | TOUGH | - |
dc.subject | POLY(EPSILON-CAPROLACTONE) | - |
dc.title | Strong and Biostable Hyaluronic Acid-Calcium Phosphate Nanocomposite Hydrogel via in Situ Precipitation Process | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Koh, Young-Hag | - |
dc.identifier.doi | 10.1021/acs.biomac.5b01557 | - |
dc.identifier.scopusid | 2-s2.0-84962788758 | - |
dc.identifier.wosid | 000372391800014 | - |
dc.identifier.bibliographicCitation | BIOMACROMOLECULES, v.17, no.3, pp.841 - 851 | - |
dc.relation.isPartOf | BIOMACROMOLECULES | - |
dc.citation.title | BIOMACROMOLECULES | - |
dc.citation.volume | 17 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 841 | - |
dc.citation.endPage | 851 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordPlus | SIMPLE SURFACE MODIFICATION | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | BIODEGRADABLE HYDROGELS | - |
dc.subject.keywordPlus | CROSS-LINKING | - |
dc.subject.keywordPlus | APATITE | - |
dc.subject.keywordPlus | COMPOSITE | - |
dc.subject.keywordPlus | CHITOSAN | - |
dc.subject.keywordPlus | COLLAGEN | - |
dc.subject.keywordPlus | TOUGH | - |
dc.subject.keywordPlus | POLY(EPSILON-CAPROLACTONE) | - |
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