Strong and Biostable Hyaluronic Acid-Calcium Phosphate Nanocomposite Hydrogel via in Situ Precipitation Process
- Authors
- Jeong, Seol-Ha; Koh, Young-Hag; Kim, Suk-Wha; Park, Ji-Ung; Kim, Hyoun-Ee; Song, Juha
- Issue Date
- 3월-2016
- Publisher
- AMER CHEMICAL SOC
- Citation
- BIOMACROMOLECULES, v.17, no.3, pp.841 - 851
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOMACROMOLECULES
- Volume
- 17
- Number
- 3
- Start Page
- 841
- End Page
- 851
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/89336
- DOI
- 10.1021/acs.biomac.5b01557
- ISSN
- 1525-7797
- Abstract
- Hyaluronic acid (HAc) hydrogel exhibits excellent biocompatibility, but it has limited biomedical application due to its poor biomechanical properties as well as too-fast enzymatic degradation. In this study, we have developed an in situ precipitation process for the fabrication of a HAc-calcium phosphate nanocomposite hydrogel, after the formation of the glycidyl methacrylate-conjugated HAc (GMHA) hydrogels via photo-cross-linking, to improve the mechanical and biological properties under physiological conditions. In particular, our process facilitates the rapid incorporation of calcium phosphate (CaP) nanoparticles of uniform size and with minimal agglomeration into a polymer matrix, homogeneously. Compared with pure HAc, the nanocomposite hydrogels exhibit improved mechanical behavior. Specifically, the shear modulus is improved by a factor of 4. The biostability of the nanocomposite hydrogel was also significantly improved compared with that of pure HAc hydrogels tinder both in vitro and in vivo conditions.
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Collections - Graduate School > Department of Bioengineering > 1. Journal Articles
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