Molecular Neurobiology and Promising New Treatment in Depression
DC Field | Value | Language |
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dc.contributor.author | Jeon, Sang Won | - |
dc.contributor.author | Kim, Yong-Ku | - |
dc.date.accessioned | 2021-09-04T02:08:42Z | - |
dc.date.available | 2021-09-04T02:08:42Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-03 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89347 | - |
dc.description.abstract | The limited effects of currently available antidepressants are becoming an urgent issue in depression research. It takes a long time to determine treatment effects, and the overall remission rate is low. Although we expect the development of non-monoamine antidepressants in the near future, efforts in this regard over the past several decades have not yet been compensated. Thus, researchers and clinicians should clarify the neurobiological mechanisms of integrated modulators that regulate changes in genes, cells, the brain, and behaviors associated with depression. In this study, we review molecular neurobiological theories and new treatments for depression. Beyond neuroanatomy and monoamine theory, we discuss cells and molecules, neural plasticity, neurotrophisms, endocrine mechanisms, immunological mechanisms, genetics, circadian rhythms, and metabolic regulation in depression. In addition, we introduce the possibility of new antidepressant drug development using protein translation signaling (mTOR) pathways. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.subject | NECROSIS-FACTOR-ALPHA | - |
dc.subject | SEROTONIN TRANSPORTER GENE | - |
dc.subject | PRO-INFLAMMATORY CYTOKINES | - |
dc.subject | D-ASPARTATE ANTAGONIST | - |
dc.subject | MAJOR DEPRESSION | - |
dc.subject | NEUROTROPHIC FACTOR | - |
dc.subject | MOOD DISORDERS | - |
dc.subject | PLASMA-LEVELS | - |
dc.subject | ANTIDEPRESSANT TREATMENT | - |
dc.subject | SOLUBLE INTERLEUKIN-2 | - |
dc.title | Molecular Neurobiology and Promising New Treatment in Depression | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Ku | - |
dc.identifier.doi | 10.3390/ijms17030381 | - |
dc.identifier.scopusid | 2-s2.0-84961251622 | - |
dc.identifier.wosid | 000373712800118 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.17, no.3 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 17 | - |
dc.citation.number | 3 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | SEROTONIN TRANSPORTER GENE | - |
dc.subject.keywordPlus | PRO-INFLAMMATORY CYTOKINES | - |
dc.subject.keywordPlus | D-ASPARTATE ANTAGONIST | - |
dc.subject.keywordPlus | MAJOR DEPRESSION | - |
dc.subject.keywordPlus | NEUROTROPHIC FACTOR | - |
dc.subject.keywordPlus | MOOD DISORDERS | - |
dc.subject.keywordPlus | PLASMA-LEVELS | - |
dc.subject.keywordPlus | ANTIDEPRESSANT TREATMENT | - |
dc.subject.keywordPlus | SOLUBLE INTERLEUKIN-2 | - |
dc.subject.keywordAuthor | gene | - |
dc.subject.keywordAuthor | BDNF | - |
dc.subject.keywordAuthor | neurobiology | - |
dc.subject.keywordAuthor | immune | - |
dc.subject.keywordAuthor | neural plasticity | - |
dc.subject.keywordAuthor | mTOR | - |
dc.subject.keywordAuthor | antidepressant | - |
dc.subject.keywordAuthor | depression | - |
dc.subject.keywordAuthor | endocrine | - |
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