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Molecular Neurobiology and Promising New Treatment in Depression

Authors
Jeon, Sang WonKim, Yong-Ku
Issue Date
3월-2016
Publisher
MDPI AG
Keywords
gene; BDNF; neurobiology; immune; neural plasticity; mTOR; antidepressant; depression; endocrine
Citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.17, no.3
Indexed
SCIE
SCOPUS
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume
17
Number
3
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/89347
DOI
10.3390/ijms17030381
ISSN
1661-6596
Abstract
The limited effects of currently available antidepressants are becoming an urgent issue in depression research. It takes a long time to determine treatment effects, and the overall remission rate is low. Although we expect the development of non-monoamine antidepressants in the near future, efforts in this regard over the past several decades have not yet been compensated. Thus, researchers and clinicians should clarify the neurobiological mechanisms of integrated modulators that regulate changes in genes, cells, the brain, and behaviors associated with depression. In this study, we review molecular neurobiological theories and new treatments for depression. Beyond neuroanatomy and monoamine theory, we discuss cells and molecules, neural plasticity, neurotrophisms, endocrine mechanisms, immunological mechanisms, genetics, circadian rhythms, and metabolic regulation in depression. In addition, we introduce the possibility of new antidepressant drug development using protein translation signaling (mTOR) pathways.
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