Evaluation of the Performance of a Fecal Tumor M2-PK Rapid Kit Using Stool Specimens for Detection of Colorectal Tumors
- Authors
- Cho, Chi Hyun; Kim, Jeeyong; Jang, Mi Ae; Lee, Beom Jae; Park, Jong-Jae; Lim, Chae Seung
- Issue Date
- 3월-2016
- Publisher
- ASSOC CLINICAL SCIENTISTS
- Keywords
- M2-PK; colorectal tumor; stool; rapid test; colonoscopy
- Citation
- ANNALS OF CLINICAL AND LABORATORY SCIENCE, v.46, no.2, pp.154 - 160
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANNALS OF CLINICAL AND LABORATORY SCIENCE
- Volume
- 46
- Number
- 2
- Start Page
- 154
- End Page
- 160
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/89353
- ISSN
- 0091-7370
- Abstract
- Background. In gastrointestinal tumors, only subunits of pyruvate kinase isoenzyme type M2 are detectable, and mainly in the dimeric form termed tumor M2-PK. A rapid test for the detection of M2PK in stool has been developed. We evaluated the performance of the M2-PK rapid kit for the detection of colorectal tumors compared with colonoscopy. Design. Stool specimens (n= 268) were obtained from patients who had a fecal occult blood test and colonoscopy performed for clinical evaluation or routine health checkup. Collected stool specimens were kept frozen at -20 degrees C until testing. The fecal tumor M2-PK test was performed using a ScheBo M2-PK Quick test (ScheBo((R)) center dot Biotech AG, Giessen, Germany). Results. A total of 236 patients were analyzed, including 87 with tubular adenoma and 126 controls. In tumor M2PK testing, 37 of 87 tubular adenoma specimens (42.5%) and 2 of 4 sessile serrated adenoma specimens (50%) tested positive. The specificity of the M2-PK rapid test was 87.3%. Conclusion. The tumor M2-PK test demonstrated moderate sensitivity for detection of colorectal adenoma. M2-PK test could be considered as a useful point-of-care testing device for detection of colorectal tumors.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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