The acceptable duration between occupational exposure to hepatitis B virus and hepatitis B immunoglobulin injection: Results from a Korean nationwide, multicenter study
- Authors
- Chang, Hyun-Ha; Lee, Won Kee; Moon, Chisook; Choi, Won Suk; Yoon, Hee-Jung; Kim, Jieun; Ryu, Seong Yeol; Kim, Hyun Ah; Jo, Yu Mi; Kwon, Ki Tae; Kim, Hye In; Sohn, Jang Wook; Yoon, Young Kyung; Jung, Sook In; Park, Kyung-Hwa; Kwon, Hyun Hee; Lee, Mi Suk; Kim, Young-Keun; Kim, Yeon Sook; Hur, Jian; Kim, Shin-Woo
- Issue Date
- 1-2월-2016
- Publisher
- MOSBY-ELSEVIER
- Keywords
- Postexposure prophylaxis; Occupational exposure; Hepatitis B virus; Health care workers; Treatment outcomes
- Citation
- AMERICAN JOURNAL OF INFECTION CONTROL, v.44, no.2, pp.189 - 193
- Indexed
- SCIE
SCOPUS
- Journal Title
- AMERICAN JOURNAL OF INFECTION CONTROL
- Volume
- 44
- Number
- 2
- Start Page
- 189
- End Page
- 193
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/89565
- DOI
- 10.1016/j.ajic.2015.08.024
- ISSN
- 0196-6553
- Abstract
- Background: Postexposure prophylaxis for occupational exposure to hepatitis B virus (HBV) plays an important role in the prevention of HBV infections in health care workers (HCWs). We examined data concerning the acceptable duration between occupational exposure and administration of a hepatitis B immunoglobulin (HBIG) injection in an occupational clinical setting. Methods: A retrospective analysis was conducted with data from 143 cases of HCWs exposed to HBV in 15 secondary and tertiary teaching hospitals between January 2005 and June 2013. Data were taken from the infection control records of each hospital. Results: Active vaccination after HBV exposure was started in 119 cases (83.2%) and postvaccination testing for hepatitis B antibody showed positive seroconversion in 93% of cases. In 98 cases (68.5%), HBIG was administered within 24 hours after HBV exposure; however, 45 HCWs (31.5%) received an HBIG injection more than 24 hours postexposure and 2 among the 45 received an injection after 7 days. Although 31.5% received an HBIG injection more than 24 hours postexposure, no cases of seroconversion to hepatitis b antibody positivity occurred. Conclusions: For susceptible HCWs, HBIG administered between 24 hours and 7 days postexposure may be as effective as administration within 24 hours in preventing occupational HBV infection. Copyright (c) 2016 by the Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.