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Aspergillus oryzae fermented germinated soybean extract alleviates perimenopausal symptoms in ovariectomised rats

Authors
Jeong, MingeumLee, Dong SungSuh, Hyung JooPark, Yooheon
Issue Date
2월-2016
Publisher
WILEY
Keywords
Aspergillus oryzae; micro-computed tomography (CT); soybeans; ovariectomised rats
Citation
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, v.96, no.3, pp.979 - 987
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
Volume
96
Number
3
Start Page
979
End Page
987
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/89601
DOI
10.1002/jsfa.7174
ISSN
0022-5142
Abstract
BACKGROUND: Soybeans have been widely used to alleviate climacteric symptoms. In this study, we investigated the oestrogenic activities of isoflavones extracted from Aspergillus oryzae-challenged germinated soybeans (AO-GS). Eight-week-old virgin Sprague-Dawley female rats were ovariectomised (OVX). The rats were orally administered 0.1mg kg(-1)d 17 alpha-ethinyloestradiol or three different doses of AO-GS (0.5, 1.0 2.0 g kg(-1) day(-1)) in distilled water for 6 weeks, while control rats were administered vehicle alone. Uterine weights and levels of oestradiol and testosterone in serum were measured. In addition to serum parameters, bone parameters were also acquired by using micro-computed tomography scanning. RESULTS: Treatments of OVX rats with AO-GS changed the secretory profile of serum oestradiol and testosterone. Serum oestradiol levels were significantly increased in OVX rats treated with and AO-GS (0.5, 1.0, 2.0 g kg-1 day-1), while serum testosterone levels were not significantly increased in OVX rats treated with 1.0 g kg-1 day-1 of AO-GS. Furthermore, AO-GS (2.0 g kg(-1) day(-1)) significantly attenuated bone loss, increased trabecular bone volume fraction and trabecular thickness, and significantly decreased trabecular pattern factor. CONCLUSION: AO-GS treatments caused moderate oestrogenic activity in OVX rats compared to those treated with oestradiol, suggesting the potential for the use of AO-GS in the treatment of menopausal symptoms and in osteoporosis caused by oestrogen deficiency. (C) 2015 Society of Chemical Industry
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Suh, Hyung Joo
보건과학대학 (바이오시스템의과학부)
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