Effect of sustained release of rhBMP-2 from dried and wet hyaluronic acid hydrogel carriers compared with direct dip coating of rhBMP-2 on peri-implant osteogenesis of dental implants in canine mandibles
DC Field | Value | Language |
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dc.contributor.author | Pan, Hui | - |
dc.contributor.author | Han, Jeong Joon | - |
dc.contributor.author | Park, Yong-Doo | - |
dc.contributor.author | Cho, Tae Hyung | - |
dc.contributor.author | Hwang, Soon Jung | - |
dc.date.accessioned | 2021-09-04T03:26:45Z | - |
dc.date.available | 2021-09-04T03:26:45Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-02 | - |
dc.identifier.issn | 1010-5182 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89644 | - |
dc.description.abstract | Hyaluronic acid (HA) hydrogel has been used as a carrier of recombinant human bone morphogenetic protein (rhBMP)-2 for sustained delivery. To enhance peri-implant osteogenesis, a dried coating of rhBMP-2 HA hydrogel (BMP-HAH) on dental implants was designed; this approach provides the advantage of omitting in situ preparation of wet HA hydrogel. Sustained release of rhBMP-2 was more efficient for dried hydrogel over wet hydrogel. For both types, the released rhBMP-2 consistently led to enhanced alkaline phosphatase activity and osterix expression in human mesenchymal stromal cells. Histomorphometric analysis 4 weeks after placement of a dental implant in canine mandibles showed that the dried coating of BMP-HAH (10 mu g/ml, n = 6) resulted in a significantly greater bone area (BA) than the wet BMP-HAH (10 mu g/ml, n = 6) (p = 0.006) and implants without any coating (n = 6) (p = 0.022), while simple dip coating with rhBMP-2 (10 mu g/ml, n = 6) resulted in significantly greater BA than the other three groups (p < 0.0005). Bone-to-implant contact (BIC) was significantly different only between the dried and wet coating of BMP-HAH (p = 0.014). Our results suggest that a simple dip coating of rhBMP-2 is more effective for increased ped-implant osteogenesis compared to a coating of BMP-HAH with sustained release. (C) 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CHURCHILL LIVINGSTONE | - |
dc.subject | BONE MORPHOGENETIC PROTEIN-2 | - |
dc.subject | MESENCHYMAL STEM-CELLS | - |
dc.subject | ANTIMICROBIAL PEPTIDES | - |
dc.subject | TISSUE REGENERATION | - |
dc.subject | TITANIUM IMPLANTS | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | IN-VITRO | - |
dc.subject | BMP-2 | - |
dc.subject | OSSEOINTEGRATION | - |
dc.subject | CARTILAGE | - |
dc.title | Effect of sustained release of rhBMP-2 from dried and wet hyaluronic acid hydrogel carriers compared with direct dip coating of rhBMP-2 on peri-implant osteogenesis of dental implants in canine mandibles | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Yong-Doo | - |
dc.identifier.doi | 10.1016/j.jcms.2015.11.018 | - |
dc.identifier.scopusid | 2-s2.0-84956631806 | - |
dc.identifier.wosid | 000369461400005 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, v.44, no.2, pp.116 - 125 | - |
dc.relation.isPartOf | JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY | - |
dc.citation.title | JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY | - |
dc.citation.volume | 44 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 116 | - |
dc.citation.endPage | 125 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Dentistry, Oral Surgery & Medicine | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Dentistry, Oral Surgery & Medicine | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | BONE MORPHOGENETIC PROTEIN-2 | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | ANTIMICROBIAL PEPTIDES | - |
dc.subject.keywordPlus | TISSUE REGENERATION | - |
dc.subject.keywordPlus | TITANIUM IMPLANTS | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | BMP-2 | - |
dc.subject.keywordPlus | OSSEOINTEGRATION | - |
dc.subject.keywordPlus | CARTILAGE | - |
dc.subject.keywordAuthor | Peri-implant osteogenesis | - |
dc.subject.keywordAuthor | Hyaluronic acid hydrogel | - |
dc.subject.keywordAuthor | Dried coating | - |
dc.subject.keywordAuthor | Dip coating | - |
dc.subject.keywordAuthor | rhBMP-2 | - |
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