Mitochondrial oxidative phosphorylation complexes exist in the sarcolemma of skeletal muscle
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyun | - |
dc.contributor.author | Kim, Seung-Hyeob | - |
dc.contributor.author | Lee, Jae-Seon | - |
dc.contributor.author | Yang, Yun-Hee | - |
dc.contributor.author | Nam, Jwa-Min | - |
dc.contributor.author | Kim, Bong-Woo | - |
dc.contributor.author | Ko, Young-Gyu | - |
dc.date.accessioned | 2021-09-04T03:36:27Z | - |
dc.date.available | 2021-09-04T03:36:27Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-02 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89723 | - |
dc.description.abstract | Although proteomic analyses have revealed the presence of mitochondrial oxidative phosphorylation (OXPHOS) proteins in the plasma membrane, there have been no in-depth evaluations of the presence or function of OXPHOS I-V in the plasma membrane. Here, we demonstrate the in situ localization of OXPHOS I-V complexes to the sarcolemma of skeletal muscle by immunofluorescence and immunohistochemistry. A portion of the OXPHOS I-V complex proteins was not co-stained with MitoTracker but co-localized with caveolin-3 in the sarcolemma of mouse gastrocnemius. Mitochondrial matrix-facing OXPHOS complex subunits were ectopically expressed in the sarcolemma of the non-permeabilized muscle fibers and C2C12 myotubes. The sarcolemmal localization of cytochrome c was also observed from mouse gastrocnemius muscles and C2C12 myotubes, as determined by confocal and total internal resonance fluorescence (TIRF) microscopy. Based on these data, we conclude that a portion of OXPHOS complexes is localized in the sarcolemma of skeletal muscle and may have non-canonical functions. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.subject | EXTRACELLULAR ATP SYNTHESIS | - |
dc.subject | RAFT PROTEOME REVEALS | - |
dc.subject | LIPID RAFTS | - |
dc.subject | SYNTHASE COMPLEX | - |
dc.subject | PLASMA-MEMBRANE | - |
dc.subject | PROTEINS | - |
dc.subject | SURFACE | - |
dc.subject | MICRODOMAINS | - |
dc.subject | CAVEOLIN-3 | - |
dc.subject | RECEPTOR | - |
dc.title | Mitochondrial oxidative phosphorylation complexes exist in the sarcolemma of skeletal muscle | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Bong-Woo | - |
dc.contributor.affiliatedAuthor | Ko, Young-Gyu | - |
dc.identifier.doi | 10.5483/BMBRep.2016.49.2.232 | - |
dc.identifier.scopusid | 2-s2.0-84960324613 | - |
dc.identifier.wosid | 000373059500009 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.49, no.2, pp.116 - 121 | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 49 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 116 | - |
dc.citation.endPage | 121 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002082413 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | EXTRACELLULAR ATP SYNTHESIS | - |
dc.subject.keywordPlus | RAFT PROTEOME REVEALS | - |
dc.subject.keywordPlus | LIPID RAFTS | - |
dc.subject.keywordPlus | SYNTHASE COMPLEX | - |
dc.subject.keywordPlus | PLASMA-MEMBRANE | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | SURFACE | - |
dc.subject.keywordPlus | MICRODOMAINS | - |
dc.subject.keywordPlus | CAVEOLIN-3 | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordAuthor | Cytochrome c | - |
dc.subject.keywordAuthor | Extracellular NADH-dependent respiration | - |
dc.subject.keywordAuthor | Oxidative phosphorylation complexes | - |
dc.subject.keywordAuthor | Sarcolemma | - |
dc.subject.keywordAuthor | Skeletal muscle | - |
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