Effects of Glycated Whey Protein Concentrate on Pro-inflammatory Cytokine Expression and Phagocytic Activity in RAW264.7 Macrophages
DC Field | Value | Language |
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dc.contributor.author | Chun, Su-Hyun | - |
dc.contributor.author | Lee, Hyun Ah | - |
dc.contributor.author | Lee, Keon Bong | - |
dc.contributor.author | Kim, Sae Hun | - |
dc.contributor.author | Park, Kun-Young | - |
dc.contributor.author | Lee, Kwang-Won | - |
dc.date.accessioned | 2021-09-04T03:38:05Z | - |
dc.date.available | 2021-09-04T03:38:05Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-02 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89735 | - |
dc.description.abstract | The aim of this study was to determine the stimulatory effects of Maillard reaction, a non-enzymatic browning reaction on the expression of pro-inflammatory cytokines and phagocytic activity induced by whey protein concentrate (WPC). Glycated WPC (G-WPC) was prepared by a reaction between WPC and the lactose it contained. The fluorescence intensity of G-WPC dramatically increased after one day, and high molecular weight complexes formed via the Maillard reaction were also observed in the sodium dodecyl sulfate-polyacrylamide gel electrophoresis profiles. G-WPC demonstrated immunomodulatory effects, including stimulation of increased nitric oxide production and cytokine expressions (i.e., tumor necrosis factor-a, interleukin (IL)-1 beta, and IL-6), compared to WPC. Furthermore, the phagocytic activity of RAW264.7 cells was significantly increased upon treatment with G-WPC, compared to WPC. Therefore, we suggest that G-WPC can be utilized as an improved dietary source for providing immune modulating activity. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC JAPAN | - |
dc.subject | NITRIC-OXIDE SYNTHASE | - |
dc.subject | NECROSIS-FACTOR-ALPHA | - |
dc.subject | FACTOR-KAPPA-B | - |
dc.subject | MAILLARD REACTION | - |
dc.subject | HEAT-TREATMENT | - |
dc.subject | BETA-LACTOGLOBULIN | - |
dc.subject | REACTION-PRODUCTS | - |
dc.subject | MILK | - |
dc.subject | PEPTIDES | - |
dc.subject | GROWTH | - |
dc.title | Effects of Glycated Whey Protein Concentrate on Pro-inflammatory Cytokine Expression and Phagocytic Activity in RAW264.7 Macrophages | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kwang-Won | - |
dc.identifier.doi | 10.1248/bpb.b15-00596 | - |
dc.identifier.scopusid | 2-s2.0-84958961722 | - |
dc.identifier.wosid | 000369124500007 | - |
dc.identifier.bibliographicCitation | BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.39, no.2, pp.199 - 206 | - |
dc.relation.isPartOf | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.title | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.volume | 39 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 199 | - |
dc.citation.endPage | 206 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | FACTOR-KAPPA-B | - |
dc.subject.keywordPlus | MAILLARD REACTION | - |
dc.subject.keywordPlus | HEAT-TREATMENT | - |
dc.subject.keywordPlus | BETA-LACTOGLOBULIN | - |
dc.subject.keywordPlus | REACTION-PRODUCTS | - |
dc.subject.keywordPlus | MILK | - |
dc.subject.keywordPlus | PEPTIDES | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordAuthor | Maillard reaction | - |
dc.subject.keywordAuthor | phagocytosis | - |
dc.subject.keywordAuthor | RAW264.7 cell | - |
dc.subject.keywordAuthor | immune enhancing activity | - |
dc.subject.keywordAuthor | glycated whey protein concentrate | - |
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