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In vivo photothermal treatment by the peritumoral injection of macrophages loaded with gold nanoshells

Authors
Yang, Taeseok DanielChoi, WonshikYoon, Tai HyunLee, Kyoung JinLee, Jae-SeungJoo, Jang HoLee, Min-GooYim, Hong SoonChoi, Kyung MinKim, ByoungjaeLee, Jung JooKim, HeejinLee, Doh YoungJung, Kwang-YoonBaek, Seung-Kuk
Issue Date
1-1월-2016
Publisher
OPTICAL SOC AMER
Keywords
Medical optics and biotechnology; Photodynamic therapy; Photothermal effects
Citation
BIOMEDICAL OPTICS EXPRESS, v.7, no.1, pp.185 - 193
Indexed
SCIE
SCOPUS
Journal Title
BIOMEDICAL OPTICS EXPRESS
Volume
7
Number
1
Start Page
185
End Page
193
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/89855
DOI
10.1364/BOE.7.000185
ISSN
2156-7085
Abstract
Photothermal treatment methods have been widely studied for their target specificity and potential for supplementing the limitations of conventional surgical treatments. In this study, we conducted in vivo photothermal treatments using macrophages containing nanoshells as live vectors. We injected macrophages at the peritumoral sites and observed that they had penetrated into the tumor approximately 48 hours after injection. Afterwards, we irradiated with a near-infrared laser for 2 minutes at 1 W/cm(2), causing cancer cell death. Our study identified the optimal conditions of the photothermal treatment and confirmed the feasibility of its use in in vivo treatments. (C) 2015 Optical Society of America
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College of Science > Department of Physics > 1. Journal Articles
College of Engineering > Department of Materials Science and Engineering > 1. Journal Articles
College of Medicine > Department of Medical Science > 1. Journal Articles
Graduate School > Department of Biomedical Sciences > 1. Journal Articles

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