Intercellular adhesion molecule-1 polymorphisms, K469E and G261R and susceptibility to vasculitis and rheumatoid arthritis: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Y. H. | - |
dc.contributor.author | Bae, S-C. | - |
dc.date.accessioned | 2021-09-04T04:51:46Z | - |
dc.date.available | 2021-09-04T04:51:46Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0145-5680 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/90109 | - |
dc.description.abstract | The aim of this study was to determine whether intercellular adhesion molecule-1 (ICAM-1) polymorphisms are associated with susceptibility to vasculitis or rheumatoid arthritis (RA). Meta-analyses were performed to assess the associations between K469E and G241R polymorphisms of ICAM-1 and vasculitis or RA. A total of 12 studies on 1,368 patients and 1,922 controls, which comprised 8 vasculitis studies and 4 RA studies, were included in the meta-analysis. We found no significant association between vasculitis and K469E E allele among the various subjects (OR = 1.238, 95% CI = 0.9781-1.566, p = 0.076). However, an association between vasculitis and K469E polymorphism was observed under homozygote contrast (OR = 1.443, 95% CI = 1.084-1.920, p = 0.012). Stratification by ethnicity and vasculitis type showed no association between vasculitis and 1 K469E polymorphism under heterozygote contrast. In addition, the meta-analysis revealed a significant association between the ICAM-1 G241R R allele and Behcet's disease (BD) (OR = 3.261, 95% CI = 1.653-6.434, p = 0.001), but not giant cell arteritis. Moreover, the meta-analysis indicated an association between RA and the R allele and RR+RG genotype of the ICAM-1 G241R polymorphism (OR = 2.014, 95% CI = 1.215-3.339, p = 0.007; OR = 2.394, 95% CI = 1.354-4.235, p = 0.003). This meta-analysis suggests that the K469E polymorphism is associated with susceptibility to vasculitis, and that the G241R polymorphism is associated with susceptibility to BD and RA. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | C M B ASSOC | - |
dc.subject | BEHCETS-DISEASE | - |
dc.subject | GENE POLYMORPHISMS | - |
dc.subject | KOREAN PATIENTS | - |
dc.subject | CELL ARTERITIS | - |
dc.subject | ASSOCIATION | - |
dc.subject | ICAM-1 | - |
dc.subject | G/A | - |
dc.title | Intercellular adhesion molecule-1 polymorphisms, K469E and G261R and susceptibility to vasculitis and rheumatoid arthritis: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Y. H. | - |
dc.identifier.doi | 10.14715/cmb/2016.62.12.15 | - |
dc.identifier.scopusid | 2-s2.0-85011995296 | - |
dc.identifier.wosid | 000396121800015 | - |
dc.identifier.bibliographicCitation | CELLULAR AND MOLECULAR BIOLOGY, v.62, no.12, pp.84 - 90 | - |
dc.relation.isPartOf | CELLULAR AND MOLECULAR BIOLOGY | - |
dc.citation.title | CELLULAR AND MOLECULAR BIOLOGY | - |
dc.citation.volume | 62 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 84 | - |
dc.citation.endPage | 90 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | BEHCETS-DISEASE | - |
dc.subject.keywordPlus | GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | KOREAN PATIENTS | - |
dc.subject.keywordPlus | CELL ARTERITIS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | ICAM-1 | - |
dc.subject.keywordPlus | G/A | - |
dc.subject.keywordAuthor | Vasculitis | - |
dc.subject.keywordAuthor | rheumatoid arthritis | - |
dc.subject.keywordAuthor | ICAM-1 | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | meta-analysis | - |
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