Intercellular adhesion molecule-1 polymorphisms, K469E and G261R and susceptibility to vasculitis and rheumatoid arthritis: a meta-analysis
- Authors
- Lee, Y. H.; Bae, S-C.
- Issue Date
- 2016
- Publisher
- C M B ASSOC
- Keywords
- Vasculitis; rheumatoid arthritis; ICAM-1; polymorphism; meta-analysis
- Citation
- CELLULAR AND MOLECULAR BIOLOGY, v.62, no.12, pp.84 - 90
- Indexed
- SCIE
SCOPUS
- Journal Title
- CELLULAR AND MOLECULAR BIOLOGY
- Volume
- 62
- Number
- 12
- Start Page
- 84
- End Page
- 90
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/90109
- DOI
- 10.14715/cmb/2016.62.12.15
- ISSN
- 0145-5680
- Abstract
- The aim of this study was to determine whether intercellular adhesion molecule-1 (ICAM-1) polymorphisms are associated with susceptibility to vasculitis or rheumatoid arthritis (RA). Meta-analyses were performed to assess the associations between K469E and G241R polymorphisms of ICAM-1 and vasculitis or RA. A total of 12 studies on 1,368 patients and 1,922 controls, which comprised 8 vasculitis studies and 4 RA studies, were included in the meta-analysis. We found no significant association between vasculitis and K469E E allele among the various subjects (OR = 1.238, 95% CI = 0.9781-1.566, p = 0.076). However, an association between vasculitis and K469E polymorphism was observed under homozygote contrast (OR = 1.443, 95% CI = 1.084-1.920, p = 0.012). Stratification by ethnicity and vasculitis type showed no association between vasculitis and 1 K469E polymorphism under heterozygote contrast. In addition, the meta-analysis revealed a significant association between the ICAM-1 G241R R allele and Behcet's disease (BD) (OR = 3.261, 95% CI = 1.653-6.434, p = 0.001), but not giant cell arteritis. Moreover, the meta-analysis indicated an association between RA and the R allele and RR+RG genotype of the ICAM-1 G241R polymorphism (OR = 2.014, 95% CI = 1.215-3.339, p = 0.007; OR = 2.394, 95% CI = 1.354-4.235, p = 0.003). This meta-analysis suggests that the K469E polymorphism is associated with susceptibility to vasculitis, and that the G241R polymorphism is associated with susceptibility to BD and RA.
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