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Flavin-mediated photo-oxidation for the detection of mitochondrial flavins
- Issue Date
- 2016
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.52, no.92, pp.13487 - 13490
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 52
- Number
- 92
- Start Page
- 13487
- End Page
- 13490
- ISSN
- 1359-7345
- Abstract
- We report a new approach for the detection of mitochondrial flavins through photo-oxidation of a probe molecule. Probe 1 showed high brightness (epsilon x Phi(f) = 6.50 x 10(3) M-1 cm(-1)) at long wavelengths (maximum emission wavelength, lambda(max) = 600 nm) upon photo-oxidation, assisted by the strong electron accepting ability of the isoalloxazine moiety in flavins. Probe 1 also exhibited high selectivity for flavins over various biological oxidants, remarkable photo-stability, and mitochondrial localization.
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Collections - College of Science > Department of Chemistry > 1. Journal Articles
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