Characterization of shear stress preventing red blood cells aggregation at the individual cell level: The temperature dependence
DC Field | Value | Language |
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dc.contributor.author | Lee, K. | - |
dc.contributor.author | Priezzhev, A. | - |
dc.contributor.author | Shin, S. | - |
dc.contributor.author | Yaya, F. | - |
dc.contributor.author | Meglinski, I. | - |
dc.date.accessioned | 2021-09-04T05:11:31Z | - |
dc.date.available | 2021-09-04T05:11:31Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1386-0291 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/90231 | - |
dc.description.abstract | BACKGROUND: The novel measure of the red blood cells (RBC) aggregation (RBC-A) -the critical (minimum) shear stress (CSS) to prevent the cells from aggregation was found to be a promising clinically significant parameter. However, the absolute values of this parameter were found to change significantly depending on the shearing geometry (cup-and-bob, cone-plate or microchannel-flow) and have different temperature dependences along with it. The direct confirmation of these dependences aimed to find out the correct values is still pending. OBJECTIVE: In this work, we aim to assess the absolute values of CSS at different temperatures. METHODS: The single cell level measurements of CSS were performed using optical tweezers. The measurements were carried out in heavily diluted suspensions of RBCs in plasma. RESULTS: The temperature dependent changes in CSS were measured at the points (22 and 38 degrees C), in which the cup-and-bob and cone-plate systems yielded about 1.5-fold different values, while the microchannel-flow system yielded a constant value. The single cell CSS were found to be 362 +/- 157mPa (22 degrees C) and 312 +/- 57mPa (38 degrees C). CONCLUSIONS: Our results prove that the microfluidic-flow approach is reflecting the RBC-A correctly. While the CSS values measured with other systems show the temperature dependent effect of the shearing geometry. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | IOS PRESS | - |
dc.title | Characterization of shear stress preventing red blood cells aggregation at the individual cell level: The temperature dependence | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, S. | - |
dc.identifier.doi | 10.3233/CH-168020 | - |
dc.identifier.scopusid | 2-s2.0-85011545729 | - |
dc.identifier.wosid | 000395934200037 | - |
dc.identifier.bibliographicCitation | CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, v.64, no.4, pp.853 - 857 | - |
dc.relation.isPartOf | CLINICAL HEMORHEOLOGY AND MICROCIRCULATION | - |
dc.citation.title | CLINICAL HEMORHEOLOGY AND MICROCIRCULATION | - |
dc.citation.volume | 64 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 853 | - |
dc.citation.endPage | 857 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordAuthor | single-cell level measurements | - |
dc.subject.keywordAuthor | temperature | - |
dc.subject.keywordAuthor | aggregation | - |
dc.subject.keywordAuthor | critical shear stress | - |
dc.subject.keywordAuthor | microfluidic flow | - |
dc.subject.keywordAuthor | optical tweezers | - |
dc.subject.keywordAuthor | Red blood cell | - |
dc.subject.keywordAuthor | shearing-geometry | - |
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