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Acid-triggered release of doxorubicin from a hydrazone-linked Gd3+-texaphyrin conjugate

Authors
Lee, Min HeeKim, Eun-JoongLee, HyunseungPark, Sun YoungHong, Kwan SooKim, Jong SeungSessler, Jonathan L.
Issue Date
2016
Publisher
ROYAL SOC CHEMISTRY
Citation
CHEMICAL COMMUNICATIONS, v.52, no.69, pp.10551 - 10554
Indexed
SCIE
SCOPUS
Journal Title
CHEMICAL COMMUNICATIONS
Volume
52
Number
69
Start Page
10551
End Page
10554
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/90237
DOI
10.1039/c6cc05673c
ISSN
1359-7345
Abstract
The hydrazone-based Gd3+-texaphyrin doxorubicin conjugate 1, releases active doxorubicin at acidic pH values, allowing its components to be followed by two complementary imaging methods, namely Off-On fluorescence enhancement and MR imaging. It thus acts as a promising theranostic agent.
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