미역줄나무 뿌리 추출물인 셀라스트롤의 비만관련 암증식 억제효과Anti-proliferative Effects of Celastrol, A Quinine Methide Triterpene Extracted from the Perennial Vine Tripterygium wilfordii, on Obesity-related Cancers
- Other Titles
- Anti-proliferative Effects of Celastrol, A Quinine Methide Triterpene Extracted from the Perennial Vine Tripterygium wilfordii, on Obesity-related Cancers
- Authors
- 박선미; 문현석
- Issue Date
- 2016
- Publisher
- 한국식품위생안전성학회
- Keywords
- celastrol; anti-proliferative effect; obesity-related cancer; signaling pathways; metabolism
- Citation
- 한국식품위생안전성학회지, v.31, no.1, pp.59 - 66
- Indexed
- KCI
- Journal Title
- 한국식품위생안전성학회지
- Volume
- 31
- Number
- 1
- Start Page
- 59
- End Page
- 66
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/90569
- ISSN
- 1229-1153
- Abstract
- It has been generally accepted that obesity and overweight are associated with metabolic diseases and cancer incidence. In fact, obesity increased risks of cancers i.e. breast, liver, pancreatic and prostate. Celastrol is a pentacyclic triterpenoid isolated from Thunder god vine, was used as a Chinese traditional medicine for treatment of inflammatory disorders such as arthritis, lupus erythematosus and Alzheimer's disease. Also, celastrol has various biological properties of chemo-preventive, neuro-protective, and anti-oxidant effects. Recent studies demonstrated that celastrol has anti-proliferation effects in different type of obesity-related cancers and suppresses tumor progression and metastasis. Anticancer effects of celastrol include regulation of NF-κB, heat shock protein, JNK, VEGF, CXCR4, Akt/mTOR, MMP-9 and so on. For these reasons, celastrol has shown to be a promising anti-tumor agent. In this review, we will address the anticancer activities and multiple mechanisms of celastrol in obesity-related cancers.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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