Correlation of B-type natriuretic peptide levels and echocardiographic parameters in preterm infants with patent ductus arteriosus
- Authors
- Jeong, H.A.; Shin, J.; Kim, E.; Lee, E.H.; Choi, B.M.; Son, C.S.; Lee, J.W.
- Issue Date
- 2016
- Publisher
- Korean Pediatric Society
- Keywords
- B-type natriuretic peptide; Echocardiography; Patent ductus arteriosus; Premature infant
- Citation
- Korean Journal of Pediatrics, v.59, no.4, pp.183 - 189
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean Journal of Pediatrics
- Volume
- 59
- Number
- 4
- Start Page
- 183
- End Page
- 189
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/91387
- DOI
- 10.3345/kjp.2016.59.4.183
- ISSN
- 1738-1061
- Abstract
- Purpose: This study aimed to evaluate the correlation, according to postnatal age, between plasma B-type natriuretic peptide (BNP) levels and echocardiographic parameters for the assessment of patent ductus arteriosus (PDA) in preterm infants with respiratory distress. Methods: We enrolled 42 preterm infants with respiratory distress who underwent serial echocardiographic evaluation with simultaneous plasma BNP measurements until ductal closure. The correlations between BNP levels and the following 4 representative echocardiographic parameters were studied: diameter of the ductus arteriosus (DA), ratio of the left atrial diameter to the aortic diameter (LA/Ao), ratio of the PDA diameter to the infant’s left pulmonary artery diameter (PDA/LPA), and the antegrade diastolic flow of LPA (DFLPA). Results: BNP levels were significantly correlated to the magnitude of the ductal shunt, comprising the DA diameter, PDA/LPA ratio, LA/Ao ratio, and antegrade DFLPA for the overall study period. The earliest significant correlation, starting from postnatal day 2, was observed between the LA/Ao ratio and BNP levels. The PDA/LPA ratio and the antegrade DFLPA showed significant correlations with BNP levels postnatal day 3 onward, and with the DA diameter, postnatal day 5 onward. Conclusion: BNP levels and echocardiographic parameters showed a positive correlation, but the significance of the correlations differed according to the postnatal age, especially during the first few days of life. © 2016 by The Korean Pediatric Society.
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