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Effect of Layer-by-Layer (LbL) encapsulation of nano-emulsified fish oil on their digestibility ex vivo and skin permeability in vitro

Authors
Jung, E.Y.Hong, K.B.Son, H.S.Suh, H.J.Park, Y.
Issue Date
2016
Publisher
Korean Society of Food Science and Nutrition
Keywords
Encapsulation; Everted intestine sac; Fish oils; Franz cell; Nano-emulcification
Citation
Preventive Nutrition and Food Science, v.21, no.2, pp.85 - 89
Indexed
SCOPUS
KCI
Journal Title
Preventive Nutrition and Food Science
Volume
21
Number
2
Start Page
85
End Page
89
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/91423
DOI
10.3746/pnf.2016.21.2.85
ISSN
2287-1098
Abstract
Omega-3 rich fish oils are extremely labile, thus requiring control of oxidation and off flavor development. A recently proposed emulsification method, layer-by-layer (LbL) deposition, was found to be a plausible method to enhance the characteristics of bioactive ingredients, especially lipids. The present work was designed to test the possibility of enhancing the uptake and utilization of omega-3 fatty acids present in fish oil. The bioavailability of nano-emulsified fish oil was monitored in terms of intestinal absorption as well as skin permeability by using the everted intestinal sac model and Franz cell model. The skin permeability and intestinal absorption characteristics was significantly improved by LbL emulsification with lecithin/chitosan/low methoxypectin. Multilayer encapsulation along with nano-emulsification can be a useful method to deliver biologically active lipids and related components, such as fish oil. The protective effect of this tool from lipid oxidation still needs to be verified. Copyright © 2016 by The Korean Society of Food Science and Nutrition. All rights Reserved.
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보건과학대학 (바이오시스템의과학부)
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