Effect of Chaenomeles sinensis Extract on Choline Acetyltransferase Activity and Trimethyltin-Induced Learning and Memory Impairment in Mice
DC Field | Value | Language |
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dc.contributor.author | Kwon, Yoon Kyung | - |
dc.contributor.author | Choi, Soo Jung | - |
dc.contributor.author | Kim, Cho Rong | - |
dc.contributor.author | Kim, Jae Kyeom | - |
dc.contributor.author | Kim, Hye Kyung | - |
dc.contributor.author | Choi, Jong Hun | - |
dc.contributor.author | Song, Sang-Wook | - |
dc.contributor.author | Kim, Chang-Ju | - |
dc.contributor.author | Park, Gwi Gun | - |
dc.contributor.author | Park, Cheung-Seog | - |
dc.contributor.author | Shin, Dong-Hoon | - |
dc.date.accessioned | 2021-09-04T09:56:34Z | - |
dc.date.available | 2021-09-04T09:56:34Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 0009-2363 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/91678 | - |
dc.description.abstract | The aim of this study was to search for a novel choline acetyltransferase (ChAT) activator from plants traditionally grown in Korea. An ethanol extract from Chaenotneles sinensis KOEHNE showed the highest ChAT-activating effect in vitro in an assay that used human neuroblastoma cells and [C-14]acetyl-CoA. The active compound was speculated to be stearic acid methyl ester (SAME). In an in vivo experiment, C. sinensis extract and SAME improved trimethyltin (TMT)-induced deficits in learning and memory in mice as assessed by a Y-maze behavioral test and a passive avoidance test. The C. sinensis extract might attenuate the TMT-induced brain disorder. This study suggests that SAME from C. sinensis might be useful in the treatment of Alzheimer's disease. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC JAPAN | - |
dc.subject | STEARIC-ACID | - |
dc.subject | ACETYLCHOLINE | - |
dc.title | Effect of Chaenomeles sinensis Extract on Choline Acetyltransferase Activity and Trimethyltin-Induced Learning and Memory Impairment in Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Cho Rong | - |
dc.contributor.affiliatedAuthor | Shin, Dong-Hoon | - |
dc.identifier.doi | 10.1248/cpb.c15-00559 | - |
dc.identifier.scopusid | 2-s2.0-84955503065 | - |
dc.identifier.wosid | 000365694900013 | - |
dc.identifier.bibliographicCitation | CHEMICAL & PHARMACEUTICAL BULLETIN, v.63, no.12, pp.1076 - 1080 | - |
dc.relation.isPartOf | CHEMICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.title | CHEMICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.volume | 63 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1076 | - |
dc.citation.endPage | 1080 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | STEARIC-ACID | - |
dc.subject.keywordPlus | ACETYLCHOLINE | - |
dc.subject.keywordAuthor | Chaenomeles sinensis | - |
dc.subject.keywordAuthor | learning | - |
dc.subject.keywordAuthor | memory | - |
dc.subject.keywordAuthor | cognitive impairment | - |
dc.subject.keywordAuthor | stearic acid methyl ester | - |
dc.subject.keywordAuthor | choline acetyltransferase | - |
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