Mussel adhesion-employed water-immiscible fluid bioadhesive for urinary fistula sealing
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyo Jeong | - |
dc.contributor.author | Hwang, Byeong Hee | - |
dc.contributor.author | Lim, Seonghye | - |
dc.contributor.author | Choi, Bong-Hyuk | - |
dc.contributor.author | Kang, Seok Ho | - |
dc.contributor.author | Cha, Hyung Joon | - |
dc.date.accessioned | 2021-09-04T10:05:45Z | - |
dc.date.available | 2021-09-04T10:05:45Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/91745 | - |
dc.description.abstract | Urinary fistulas, abnormal openings of a urinary tract organ, are serious complications and conventional management strategies are not satisfactory. For more effective and non-invasive fistula repair, fluid tissue adhesives or sealants have been suggested. However, conventional products do not provide a suitable solution due to safety problems and poor underwater adhesion under physiological conditions. Herein, we proposed a unique water-immiscible mussel protein-based bioadhesive (WIMBA) exhibiting strong underwater adhesion which was employed by two adhesion strategies of marine organisms; 3,4-dihydroxy-L-phenylalanine (DOPA)-mediated strong adhesion and water-immiscible coacervation. The developed biocompatible WIMBA successfully sealed ex vivo urinary fistulas and provided good durability and high compliance. Thus, WIMBA could be used as a promising sealant for urinary fistula management with further expansion to diverse internal body applications. (C) 2015 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | FIBRIN SEALANT | - |
dc.subject | PROTEIN | - |
dc.subject | STRENGTH | - |
dc.subject | BYSSUS | - |
dc.title | Mussel adhesion-employed water-immiscible fluid bioadhesive for urinary fistula sealing | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Seok Ho | - |
dc.identifier.doi | 10.1016/j.biomaterials.2015.08.055 | - |
dc.identifier.scopusid | 2-s2.0-84943232615 | - |
dc.identifier.wosid | 000362926600010 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.72, pp.104 - 111 | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 72 | - |
dc.citation.startPage | 104 | - |
dc.citation.endPage | 111 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | FIBRIN SEALANT | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | STRENGTH | - |
dc.subject.keywordPlus | BYSSUS | - |
dc.subject.keywordAuthor | Underwater adhesion | - |
dc.subject.keywordAuthor | Urinary fistula | - |
dc.subject.keywordAuthor | Mussel adhesive proteins | - |
dc.subject.keywordAuthor | Complex coacervation | - |
dc.subject.keywordAuthor | DOPA | - |
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