Mussel adhesion-employed water-immiscible fluid bioadhesive for urinary fistula sealing
- Authors
- Kim, Hyo Jeong; Hwang, Byeong Hee; Lim, Seonghye; Choi, Bong-Hyuk; Kang, Seok Ho; Cha, Hyung Joon
- Issue Date
- 12월-2015
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Underwater adhesion; Urinary fistula; Mussel adhesive proteins; Complex coacervation; DOPA
- Citation
- BIOMATERIALS, v.72, pp.104 - 111
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOMATERIALS
- Volume
- 72
- Start Page
- 104
- End Page
- 111
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/91745
- DOI
- 10.1016/j.biomaterials.2015.08.055
- ISSN
- 0142-9612
- Abstract
- Urinary fistulas, abnormal openings of a urinary tract organ, are serious complications and conventional management strategies are not satisfactory. For more effective and non-invasive fistula repair, fluid tissue adhesives or sealants have been suggested. However, conventional products do not provide a suitable solution due to safety problems and poor underwater adhesion under physiological conditions. Herein, we proposed a unique water-immiscible mussel protein-based bioadhesive (WIMBA) exhibiting strong underwater adhesion which was employed by two adhesion strategies of marine organisms; 3,4-dihydroxy-L-phenylalanine (DOPA)-mediated strong adhesion and water-immiscible coacervation. The developed biocompatible WIMBA successfully sealed ex vivo urinary fistulas and provided good durability and high compliance. Thus, WIMBA could be used as a promising sealant for urinary fistula management with further expansion to diverse internal body applications. (C) 2015 Elsevier Ltd. All rights reserved.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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