Improvement of liver function and non-invasive fibrosis markers in hepatitis B virus-associated cirrhosis: 2years of entecavir treatment
- Authors
- Shin, Seung Kak; Kim, Jeong Han; Park, Hyeonsu; Kwon, Oh Sang; Lee, Hyun Jung; Yeon, Jong Eun; Byun, Kwan Soo; Suh, Sang Jun; Yim, Hyung Joon; Kim, Yun Soo; Kim, Ju Hyun
- Issue Date
- 12월-2015
- Publisher
- WILEY-BLACKWELL
- Keywords
- entecavir; hepatitis B virus; liver fibrosis; liver function
- Citation
- JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.30, no.12, pp.1775 - 1781
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Volume
- 30
- Number
- 12
- Start Page
- 1775
- End Page
- 1781
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/91777
- DOI
- 10.1111/jgh.13020
- ISSN
- 0815-9319
- Abstract
- Background and Aim: Entecavir (ETV) induces biochemical and histologic improvement of the liver in patients with chronic hepatitis B. This study aimed to confirm that 2 years of ETV treatment improves liver function and non-invasive fibrosis markers in patients with hepatitis B virus (HBV)-associated cirrhosis. Methods: A total 472 naive patients with HBV-associated cirrhosis was treated with ETV for at least 2 years, between March 2007 and December 2012. Model for end-stage liver disease and Child-Pugh (CP) score were used to evaluate the improvement of liver function. Aspartate transaminase to platelet ratio index, FIB-4 index, and fibrosis index were used to evaluate the improvement of fibrosis. Results: The final 370 of 472 patients with HBV-associated cirrhosis were enrolled. Mean age was 51 +/- 10 years, and 240 patients (64.9%) were men. The distribution of CP class was 71.1% in A, 24.6% in B, and 4.3% in C. Mean end-stage liver disease and CP score changed over the study period from 8.5 +/- 4.6 to 6.2 +/- 4.2 (P<0.001) and from 6.2 +/- 1.6 to 5.6 +/- 0.9 (P<0.001), respectively. Aspartate transaminase to platelet ratio index, FIB-4 index, and fibrosis index changed from 3.6 +/- 4.5 to 1.5 +/- 1.5 (P<0.001), from 7.0 +/- 6.2 to 3.9 +/- 2.8 (P<0.001), and from 3.3 +/- 0.9 to 2.5 +/- 1.1 (P<0.001), respectively. Conclusions: After 2 years of treatment, ETV improves liver function and non-invasive fibrosis markers in patients with HBV-associated cirrhosis.
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