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HepG2 Cell Resistance against Camptothecin from a Lysosomal Drug Delivery
- Authors
- Lee, Hoyeon; Uhm, Soojin; Shin, Jung-Won; Jeon, Hyun Mi; Dongbang, Sun; Jung, Hyo Sung; Na, Yun-Cheol; Kang, Chulhun; Kim, Jong Seung
- Issue Date
- 12월-2015
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- anticancer drugs; camptothecin; cancer; drug delivery; galactose
- Citation
- CHEMISTRY-AN ASIAN JOURNAL, v.10, no.12, pp.2694 - 2699
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMISTRY-AN ASIAN JOURNAL
- Volume
- 10
- Number
- 12
- Start Page
- 2694
- End Page
- 2699
- ISSN
- 1861-4728
- Abstract
- A galactose-appended drug delivery system released camptothecin (CPT) to lysosomes of HepG2 hepatoma cells, resulting in the cell resistance to the anticancer drug. We found that the resistance to CPT is caused by alteration of the drug release from the prodrug in lysosomes, emphasizing that the final delivery locations may critically influence drug efficacy.
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Collections - College of Science > Department of Chemistry > 1. Journal Articles
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