Hemorheological Approach for Early Detection of Chronic Kidney Disease and Diabetic Nephropathy in Type 2 Diabetes
DC Field | Value | Language |
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dc.contributor.author | Lee, Seohui | - |
dc.contributor.author | Lee, Min Young | - |
dc.contributor.author | Nam, Ji Sun | - |
dc.contributor.author | Kang, Shinae | - |
dc.contributor.author | Park, Jong Suk | - |
dc.contributor.author | Shin, Sehyun | - |
dc.contributor.author | Ahn, Chul Woo | - |
dc.contributor.author | Kim, Kyung Rae | - |
dc.date.accessioned | 2021-09-04T10:50:22Z | - |
dc.date.available | 2021-09-04T10:50:22Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2015-11-01 | - |
dc.identifier.issn | 1520-9156 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/91959 | - |
dc.description.abstract | Background: Hemorheologic alterations or changes in blood viscosity have been suggested to play a role in the pathogenesis of microvascular complications in diabetes. We measured various hemorheologic parameters in type 2 diabetes patients at different stages of chronic kidney disease (CKD) and assessed their possible role as early markers of diabetic nephropathy and renal insufficiency. Subjects and Methods: One hundred-five patients with type 2 diabetes were divided into four groups according to glomerular filtration rate (GFR), which represents the kidney function. Hemorheologic parameters, including erythrocyte deformability, fibrinogen/elongation index (EI), and aggregation index (AI) were measured using a microfluidic hemorheometer, and critical shear stress (CSS) was measured using a microfluidic technique. Various metabolic parameters were assessed from fasting blood samples, and the urine albumin-to-creatinine ratio (ACR) was calculated from first morning voided urine. Results: There were significant differences in red blood cell (RBC) deformability, AI, CSS, fibrinogen/EI, and ACR among patients in different stages of CKD (all P<0.05). RBC deformability and fibrinogen/EI significantly differed between normal (GFR >90mL/min/1.73m(2)) and CKD stage 2 (GFR 60-90mL/min/1.73m(2)) patients, whereas there was no such difference in ACR. In multiple regression analysis, fibrinogen/EI under a moderate shear stress of 3Pa was an independent predictor of GFR (=-0.328, P<0.05). Also, AI, CSS, and fibrinogen/EI were significantly different among patients at different stages of diabetic nephropathy, with a significant difference in fibrinogen/EI between normal and microalbuminuric patients (all P<0.05). Conclusions: RBC deformability and fibrinogen/EI are sensitive parameters measured via point-of-care testing for detecting erythrocyte alterations in early CKD and nephropathy in patients with type 2 diabetes. Further studies are warranted to verify their use as screening tools for diabetic nephropathy and renal impairment. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.subject | ERYTHROCYTE SEDIMENTATION-RATE | - |
dc.subject | BLOOD-CELL DEFORMABILITY | - |
dc.subject | MICROALBUMINURIA | - |
dc.subject | AGGREGATION | - |
dc.subject | ASSOCIATION | - |
dc.subject | IMPAIRMENT | - |
dc.subject | FIBRINOGEN | - |
dc.subject | RHEOLOGY | - |
dc.subject | MELLITUS | - |
dc.title | Hemorheological Approach for Early Detection of Chronic Kidney Disease and Diabetic Nephropathy in Type 2 Diabetes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Sehyun | - |
dc.identifier.doi | 10.1089/dia.2014.0295 | - |
dc.identifier.scopusid | 2-s2.0-84946397882 | - |
dc.identifier.wosid | 000364229300010 | - |
dc.identifier.bibliographicCitation | DIABETES TECHNOLOGY & THERAPEUTICS, v.17, no.11, pp.808 - 815 | - |
dc.relation.isPartOf | DIABETES TECHNOLOGY & THERAPEUTICS | - |
dc.citation.title | DIABETES TECHNOLOGY & THERAPEUTICS | - |
dc.citation.volume | 17 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 808 | - |
dc.citation.endPage | 815 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | ERYTHROCYTE SEDIMENTATION-RATE | - |
dc.subject.keywordPlus | BLOOD-CELL DEFORMABILITY | - |
dc.subject.keywordPlus | MICROALBUMINURIA | - |
dc.subject.keywordPlus | AGGREGATION | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | IMPAIRMENT | - |
dc.subject.keywordPlus | FIBRINOGEN | - |
dc.subject.keywordPlus | RHEOLOGY | - |
dc.subject.keywordPlus | MELLITUS | - |
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