Hemorheological Approach for Early Detection of Chronic Kidney Disease and Diabetic Nephropathy in Type 2 Diabetes
- Authors
- Lee, Seohui; Lee, Min Young; Nam, Ji Sun; Kang, Shinae; Park, Jong Suk; Shin, Sehyun; Ahn, Chul Woo; Kim, Kyung Rae
- Issue Date
- 1-11월-2015
- Publisher
- MARY ANN LIEBERT, INC
- Citation
- DIABETES TECHNOLOGY & THERAPEUTICS, v.17, no.11, pp.808 - 815
- Indexed
- SCIE
SCOPUS
- Journal Title
- DIABETES TECHNOLOGY & THERAPEUTICS
- Volume
- 17
- Number
- 11
- Start Page
- 808
- End Page
- 815
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/91959
- DOI
- 10.1089/dia.2014.0295
- ISSN
- 1520-9156
- Abstract
- Background: Hemorheologic alterations or changes in blood viscosity have been suggested to play a role in the pathogenesis of microvascular complications in diabetes. We measured various hemorheologic parameters in type 2 diabetes patients at different stages of chronic kidney disease (CKD) and assessed their possible role as early markers of diabetic nephropathy and renal insufficiency. Subjects and Methods: One hundred-five patients with type 2 diabetes were divided into four groups according to glomerular filtration rate (GFR), which represents the kidney function. Hemorheologic parameters, including erythrocyte deformability, fibrinogen/elongation index (EI), and aggregation index (AI) were measured using a microfluidic hemorheometer, and critical shear stress (CSS) was measured using a microfluidic technique. Various metabolic parameters were assessed from fasting blood samples, and the urine albumin-to-creatinine ratio (ACR) was calculated from first morning voided urine. Results: There were significant differences in red blood cell (RBC) deformability, AI, CSS, fibrinogen/EI, and ACR among patients in different stages of CKD (all P<0.05). RBC deformability and fibrinogen/EI significantly differed between normal (GFR >90mL/min/1.73m(2)) and CKD stage 2 (GFR 60-90mL/min/1.73m(2)) patients, whereas there was no such difference in ACR. In multiple regression analysis, fibrinogen/EI under a moderate shear stress of 3Pa was an independent predictor of GFR (=-0.328, P<0.05). Also, AI, CSS, and fibrinogen/EI were significantly different among patients at different stages of diabetic nephropathy, with a significant difference in fibrinogen/EI between normal and microalbuminuric patients (all P<0.05). Conclusions: RBC deformability and fibrinogen/EI are sensitive parameters measured via point-of-care testing for detecting erythrocyte alterations in early CKD and nephropathy in patients with type 2 diabetes. Further studies are warranted to verify their use as screening tools for diabetic nephropathy and renal impairment.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Engineering > Department of Mechanical Engineering > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.