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Impact of gastrointestinal bypass on nonmorbidly obese type 2 diabetes mellitus patients after gastrectomy

Authors
Pak, JunKwon, YeongkeunLo Menzo, EmanuelePark, SungsooSzomstein, SamuelRosenthal, Raul J.
Issue Date
11월-2015
Publisher
ELSEVIER SCIENCE INC
Keywords
Type 2 DM; Bariatric surgery; BMI; Predictor; Gastrectomy
Citation
SURGERY FOR OBESITY AND RELATED DISEASES, v.11, no.6, pp.1266 - 1272
Indexed
SCIE
SCOPUS
Journal Title
SURGERY FOR OBESITY AND RELATED DISEASES
Volume
11
Number
6
Start Page
1266
End Page
1272
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/92020
DOI
10.1016/j.soard.2014.12.008
ISSN
1550-7289
Abstract
Background: Our objective was to investigate the predictive preoperative factors and surgical components for type 2 diabetes mellitus (T2D) improvement in patients with body mass index (BMI) <35 kg/m(2). Methods: All patients undergoing curative surgical resection for gastric cancer involving Billroth I gastroduodenal anastomosis, Billroth II gastrojejunal anastomosis (B-I, B-II), or Roux-en-Y total gastrectomy (RYTG), from 2008-2011, were retrospectively reviewed. Of these, 90 patients with T2D were analyzed. The study population was divided into the "improved" and "not improved" groups. The preoperative and postoperative data were assessed using multiple logistic regression analysis. To assess the necessary surgical elements, the gastrointestinal reconstruction methods were categorized according to the presence of the fundus and gastrointestinal bypass. Results: Fifty-four patients (60%) experienced improvements in their T2D 2 years after surgery. Lower preoperative glycated hemoglobin (A1C) (odds ratio [OR]:.502; 95% confidence interval [CI]:.313.804; P =.004), not using multiple oral antidiabetic medications (OR:.341; 95% CI:.120.969; P =.043), and high BMI before surgery (OR: 1.294; 95% CI: 1.074-1.559; P =.007) were identified as independent predictors of T2D improvements. RYTG was more effective at improving T2D than B-I (OR:.160; 95% CI:.032.794; P =.025). Statistical analysis according to the surgical elements showed that the bypass procedure was associated with T2D improvements (OR: 3.023; 95% CI:.989-9.240; P =.052). Conclusion: Gastrointestinal bypass significantly contributes to T2D improvements in patients with BMI <35 kg/m(2). Low A1C, high BMI, and not using multiple antidiabetic medications were important predictors of T2D improvement. (C) 2015 American Society for Metabolic and Bariatric Surgery. All rights reserved.
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