Meta-analysis of associations between MTHFR and GST polymorphisms and susceptibility to multiple sclerosis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Seo, Young Ho | - |
dc.contributor.author | Kim, Jae-Hoon | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-04T11:02:28Z | - |
dc.date.available | 2021-09-04T11:02:28Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.issn | 1590-1874 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/92043 | - |
dc.description.abstract | We examined whether methylenetetrahydrofolate reductase (MTHFR) and glutathione S-transferase (GST) polymorphisms are associated with susceptibility to multiple sclerosis (MS). We performed a meta-analysis on the association between MS and the following genotypes: MTHFR C677T, A1298C, and GSTP1 A313G polymorphisms, and GSTM1 and GSTT1 null alleles. Fifteen comparisons involving 2,486 patients and 2,861 controls were considered. Meta-analysis of all study subjects considered together showed no association between MS and the MTHFR 677 T allele (OR = 1.014, 95 % CI 0.803-1.280, p = 0.909). Stratification by ethnicity showed no similar association in Caucasian and Arab populations. Likewise, no link was found between MS and the MTHFR 1298 C allele in the total data (OR = 2.477, 95 % CI 0.507-12.10, p = 0.263), nor when it was stratified by ethnicity. No association with MS was observed in relation to the GSTM1 null genotype in Caucasian populations (OR = 1.229, 95 % CI 0.693-2.181, p = 0.481), nor with the GSTP1 A313G polymorphism (OR for G allele = 1.133, 95 % CI 0.903-1.421, p = 0.281). However, there was an association between MS and the GSTT1 null genotype in data obtained from Caucasian populations (OR = 1.945, 95 % CI 1.452-2.605, p = 8.6 x 10(-7)). GSTT1 null genotype is associated with MS in Caucasian populations; however, no association was found between MS and polymorphisms of MTHFR, GSTM1, and GSTP1. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER-VERLAG ITALIA SRL | - |
dc.subject | METHYLENETETRAHYDROFOLATE REDUCTASE GENE | - |
dc.subject | RHEUMATOID-ARTHRITIS SUSCEPTIBILITY | - |
dc.subject | S-TRANSFERASE T1 | - |
dc.subject | C677T POLYMORPHISM | - |
dc.subject | DISEASE | - |
dc.subject | A1298C | - |
dc.subject | RISK | - |
dc.title | Meta-analysis of associations between MTHFR and GST polymorphisms and susceptibility to multiple sclerosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.contributor.affiliatedAuthor | Ji, Jong Dae | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1007/s10072-015-2318-7 | - |
dc.identifier.scopusid | 2-s2.0-84945435251 | - |
dc.identifier.wosid | 000364022100014 | - |
dc.identifier.bibliographicCitation | NEUROLOGICAL SCIENCES, v.36, no.11, pp.2089 - 2096 | - |
dc.relation.isPartOf | NEUROLOGICAL SCIENCES | - |
dc.citation.title | NEUROLOGICAL SCIENCES | - |
dc.citation.volume | 36 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2089 | - |
dc.citation.endPage | 2096 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | METHYLENETETRAHYDROFOLATE REDUCTASE GENE | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS SUSCEPTIBILITY | - |
dc.subject.keywordPlus | S-TRANSFERASE T1 | - |
dc.subject.keywordPlus | C677T POLYMORPHISM | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | A1298C | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | Multiple sclerosis | - |
dc.subject.keywordAuthor | MTHFR | - |
dc.subject.keywordAuthor | GSTs | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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