Meta-analysis of associations between MTHFR and GST polymorphisms and susceptibility to multiple sclerosis
- Authors
- Lee, Young Ho; Seo, Young Ho; Kim, Jae-Hoon; Choi, Sung Jae; Ji, Jong Dae; Song, Gwan Gyu
- Issue Date
- 11월-2015
- Publisher
- SPRINGER-VERLAG ITALIA SRL
- Keywords
- Multiple sclerosis; MTHFR; GSTs; Polymorphism; Meta-analysis
- Citation
- NEUROLOGICAL SCIENCES, v.36, no.11, pp.2089 - 2096
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROLOGICAL SCIENCES
- Volume
- 36
- Number
- 11
- Start Page
- 2089
- End Page
- 2096
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/92043
- DOI
- 10.1007/s10072-015-2318-7
- ISSN
- 1590-1874
- Abstract
- We examined whether methylenetetrahydrofolate reductase (MTHFR) and glutathione S-transferase (GST) polymorphisms are associated with susceptibility to multiple sclerosis (MS). We performed a meta-analysis on the association between MS and the following genotypes: MTHFR C677T, A1298C, and GSTP1 A313G polymorphisms, and GSTM1 and GSTT1 null alleles. Fifteen comparisons involving 2,486 patients and 2,861 controls were considered. Meta-analysis of all study subjects considered together showed no association between MS and the MTHFR 677 T allele (OR = 1.014, 95 % CI 0.803-1.280, p = 0.909). Stratification by ethnicity showed no similar association in Caucasian and Arab populations. Likewise, no link was found between MS and the MTHFR 1298 C allele in the total data (OR = 2.477, 95 % CI 0.507-12.10, p = 0.263), nor when it was stratified by ethnicity. No association with MS was observed in relation to the GSTM1 null genotype in Caucasian populations (OR = 1.229, 95 % CI 0.693-2.181, p = 0.481), nor with the GSTP1 A313G polymorphism (OR for G allele = 1.133, 95 % CI 0.903-1.421, p = 0.281). However, there was an association between MS and the GSTT1 null genotype in data obtained from Caucasian populations (OR = 1.945, 95 % CI 1.452-2.605, p = 8.6 x 10(-7)). GSTT1 null genotype is associated with MS in Caucasian populations; however, no association was found between MS and polymorphisms of MTHFR, GSTM1, and GSTP1.
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