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Microstructure and Magnetic Properties of LaSrMnO Nanoparticles and Their Application to Cardiac Immunoassay
- Authors
- Ham, Woo Seung; Kim, Min Kyung; Gim, Ji Seok; Lee, Ji Sung; Wu, Jun Hua; Lee, Kyu Back; Kim, Young Keun
- Issue Date
- Nov-2015
- Publisher
- IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
- Keywords
- Cardiac troponin I (cTnI); Curie temperature; immunoassay; LaSrMnO nanoparticles (NPs)
- Citation
- IEEE TRANSACTIONS ON MAGNETICS, v.51, no.11
- Indexed
- SCIE
SCOPUS
- Journal Title
- IEEE TRANSACTIONS ON MAGNETICS
- Volume
- 51
- Number
- 11
- ISSN
- 0018-9464
- Abstract
- Though enzyme-linked immunosorbent assay is widely used in laboratory medicine, it has limitations due to interactions between enzymes and secondary antibodies. Here, we propose a new cardiac assay scheme for detecting troponin I antigens based on La(1-x)SrxMnO3 (x = 0.10, 0.15, and 0.25) nanoparticles (NPs). These NPs are synthesized via a modified polyol process followed by heat treatment. An increase in x induces changes in crystal structure and increases both Curie temperature and saturation magnetization. The NPs with x = 0.15 exhibit a Curie temperature close to the human body temperature. The limit of detection is found to be 0.78 ng/mL. We also confirm that LaSrMnO NPs are reusable after heating the assay plate.
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Related Researcher
- Kim, Young Keun
- College of Engineering (Department of Materials Science and Engineering)