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Microstructure and Magnetic Properties of LaSrMnO Nanoparticles and Their Application to Cardiac Immunoassay

Authors
Ham, Woo SeungKim, Min KyungGim, Ji SeokLee, Ji SungWu, Jun HuaLee, Kyu BackKim, Young Keun
Issue Date
11월-2015
Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
Keywords
Cardiac troponin I (cTnI); Curie temperature; immunoassay; LaSrMnO nanoparticles (NPs)
Citation
IEEE TRANSACTIONS ON MAGNETICS, v.51, no.11
Indexed
SCIE
SCOPUS
Journal Title
IEEE TRANSACTIONS ON MAGNETICS
Volume
51
Number
11
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/92112
DOI
10.1109/TMAG.2015.2438021
ISSN
0018-9464
Abstract
Though enzyme-linked immunosorbent assay is widely used in laboratory medicine, it has limitations due to interactions between enzymes and secondary antibodies. Here, we propose a new cardiac assay scheme for detecting troponin I antigens based on La(1-x)SrxMnO3 (x = 0.10, 0.15, and 0.25) nanoparticles (NPs). These NPs are synthesized via a modified polyol process followed by heat treatment. An increase in x induces changes in crystal structure and increases both Curie temperature and saturation magnetization. The NPs with x = 0.15 exhibit a Curie temperature close to the human body temperature. The limit of detection is found to be 0.78 ng/mL. We also confirm that LaSrMnO NPs are reusable after heating the assay plate.
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Graduate School > Department of Bioengineering > 1. Journal Articles
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