Association between FOXP3 polymorphisms and susceptibility to autoimmune diseases: A meta-analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Min-Gu | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-04T11:41:00Z | - |
dc.date.available | 2021-09-04T11:41:00Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2015-10-03 | - |
dc.identifier.issn | 0891-6934 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/92212 | - |
dc.description.abstract | Objective: The aim of this study was to explore whether the FOXP3 -3279 A/C polymorphism and (GT)n microsatellite polymorphisms are associated with susceptibility to autoimmune diseases. Methods: A meta-analysis was conducted on the associations between the FOXP3 -3279 A/C polymorphism and (GT)(15) and (GT)(16) polymorphisms and autoimmune diseases. Results: Twenty-two comparative studies with a total of 7962 patients and 7453 controls were included in the meta-analysis. Meta-analysis revealed an association between autoimmune disease and the FOXP3 -3279 AA+AC genotype (OR=1.480, 95% CI=1.263-1.614, p<1.0x10(-9)), and stratification by ethnicity indicated a significant association between the FOXP3 -3279 AA+AC genotype and autoimmune diseases in Asians (OR=1.416, 95% CI=1.225-1.637, p=2.5x10(-7)) and non-Caucasians (OR=1.432, 95% CI=1.245-1.647, p=7.5x10(-8)). In addition, corrected p values for multiple testing remained significant. Meta-analysis revealed no association between autoimmune disease and the FOXP3 (GT)(15) allele (OR=1.051, 95% CI=0.933-1.183, p=0.413). Similarly, the FOXP3 (GT)(16) allele showed no associations with autoimmune disease. Conclusions: This meta-analysis indicates that the FOXP3 -3279 A/C polymorphism is associated with susceptibility to autoimmune disease in Asians and non-Caucasians. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | FOXP3/SCURFIN GENE | - |
dc.subject | GT MICROSATELLITE | - |
dc.subject | RS3761548 | - |
dc.subject | JAPANESE | - |
dc.subject | PROMOTER | - |
dc.subject | REGION | - |
dc.title | Association between FOXP3 polymorphisms and susceptibility to autoimmune diseases: A meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.3109/08916934.2015.1045582 | - |
dc.identifier.scopusid | 2-s2.0-84946556301 | - |
dc.identifier.wosid | 000365611400004 | - |
dc.identifier.bibliographicCitation | AUTOIMMUNITY, v.48, no.7, pp.445 - 452 | - |
dc.relation.isPartOf | AUTOIMMUNITY | - |
dc.citation.title | AUTOIMMUNITY | - |
dc.citation.volume | 48 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 445 | - |
dc.citation.endPage | 452 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | RS3761548 | - |
dc.subject.keywordPlus | JAPANESE | - |
dc.subject.keywordPlus | PROMOTER | - |
dc.subject.keywordPlus | REGION | - |
dc.subject.keywordPlus | FOXP3/SCURFIN GENE | - |
dc.subject.keywordPlus | GT MICROSATELLITE | - |
dc.subject.keywordAuthor | Autoimmune diseases | - |
dc.subject.keywordAuthor | FOXP3 | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | meta-analysis | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.