Association between FOXP3 polymorphisms and susceptibility to autoimmune diseases: A meta-analysis
- Authors
- Lee, Min-Gu; Bae, Sang-Cheol; Lee, Young Ho
- Issue Date
- 3-10월-2015
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Autoimmune diseases; FOXP3; polymorphism; meta-analysis
- Citation
- AUTOIMMUNITY, v.48, no.7, pp.445 - 452
- Indexed
- SCIE
SCOPUS
- Journal Title
- AUTOIMMUNITY
- Volume
- 48
- Number
- 7
- Start Page
- 445
- End Page
- 452
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/92212
- DOI
- 10.3109/08916934.2015.1045582
- ISSN
- 0891-6934
- Abstract
- Objective: The aim of this study was to explore whether the FOXP3 -3279 A/C polymorphism and (GT)n microsatellite polymorphisms are associated with susceptibility to autoimmune diseases. Methods: A meta-analysis was conducted on the associations between the FOXP3 -3279 A/C polymorphism and (GT)(15) and (GT)(16) polymorphisms and autoimmune diseases. Results: Twenty-two comparative studies with a total of 7962 patients and 7453 controls were included in the meta-analysis. Meta-analysis revealed an association between autoimmune disease and the FOXP3 -3279 AA+AC genotype (OR=1.480, 95% CI=1.263-1.614, p<1.0x10(-9)), and stratification by ethnicity indicated a significant association between the FOXP3 -3279 AA+AC genotype and autoimmune diseases in Asians (OR=1.416, 95% CI=1.225-1.637, p=2.5x10(-7)) and non-Caucasians (OR=1.432, 95% CI=1.245-1.647, p=7.5x10(-8)). In addition, corrected p values for multiple testing remained significant. Meta-analysis revealed no association between autoimmune disease and the FOXP3 (GT)(15) allele (OR=1.051, 95% CI=0.933-1.183, p=0.413). Similarly, the FOXP3 (GT)(16) allele showed no associations with autoimmune disease. Conclusions: This meta-analysis indicates that the FOXP3 -3279 A/C polymorphism is associated with susceptibility to autoimmune disease in Asians and non-Caucasians.
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