Associations between major histocompatibility complex class I chain-related gene A polymorphisms and susceptibility to Behcet's disease A meta-analysis

Abstract

The purpose of this work was to investigate whether major histocompatibility complex class I chain-related gene A (MICA) polymorphisms are associated with susceptibility to Behcet's disease (BD). A meta-analysis was conducted on the associations between the MICA-transmembrane (TM) A6 allele and the 009 allele of MICA exon 2-4 (MICA*009) and BD with or without HLA-B51 overall and in each ethnic group. Fifteen comparison studies were included in this meta-analysis. The meta-analysis revealed a significant association between the MICA-TM A6 allele and BD in European, Asian, and Arab populations [odds ratio (OR) 1.436, 95 % confidence interval (CI) 1.111-1.857, p = 0.006; OR 1.999, 95 % CI 1.551-2.575, p = 8.0 x 10(-8); OR 1.333, 95 % CI 1.058-2.300, p = 0.025, respectively,]). Stratification by HLA-B51 showed an association between the MICA-TM A6 allele and BD with HLA-B51 in the overall group and in the European population. Meta-analysis showed a significant association between the MICA*009 allele and BD in the overall group (OR 3.948, 95 % CI 2.680-5.815, p < 1.0 x 10(-8)) and in the European population (OR 3.392, 95 % CI 2.118-5.433, p = 5.6 x 10(-6)). A significant association was found between the MICA*009 allele and B51-positive BD. This meta-analysis shows that the MICA-TM A6 allele and the MICA*009 allele are associated with BD susceptibility in various ethnic populations, and that MICA alleles are in strong linkage disequilibrium with HLA-B51 in BD.