Profilin 2 promotes migration, invasion, and stemness of HT29 human colorectal cancer stem cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Min-Jung | - |
dc.contributor.author | Lee, Yoo-Sun | - |
dc.contributor.author | Han, Gi-Yeon | - |
dc.contributor.author | Lee, Han-Na | - |
dc.contributor.author | Ahn, Chiyoung | - |
dc.contributor.author | Kim, Chan-Wha | - |
dc.date.accessioned | 2021-09-04T12:47:03Z | - |
dc.date.available | 2021-09-04T12:47:03Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-09-02 | - |
dc.identifier.issn | 0916-8451 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/92509 | - |
dc.description.abstract | We investigated the role of profilin 2 in the stemness, migration, and invasion of HT29 cancer stem cells (CSCs). Increased and decreased levels of profilin 2 significantly enhanced and suppressed the self-renewal, migration, and invasion ability of HT29 CSCs, respectively. Moreover, profilin 2 directly regulated the expression of stemness markers (CD133, SOX2, and beta-catenin) and epithelial mesenchymal transition (EMT) markers (E-cadherin and snail). CD133 and beta-catenin were up-regulated by overexpression of profilin 2 and down-regulated by depletion of profilin 2. SOX2 was decreased by profilin 2 depletion. E-cadherin was not influenced by profilin 2- overexpression but increased by profilin 2- knockdown. The expression of snail was suppressed by profilin 2- knockdown. We speculated that stemness and the EMT are closely linked through profilin 2-related pathways. Therefore, this study indicates that profilin 2 affects the metastatic potential and stemness of colorectal CSCs by regulating EMT- and stemness-related proteins. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | TUMOR-INITIATING CELLS | - |
dc.subject | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject | ARP2/3 COMPLEX | - |
dc.subject | PROTEIN | - |
dc.subject | IDENTIFICATION | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | ADHESION | - |
dc.subject | CADHERIN | - |
dc.subject | CLONING | - |
dc.subject | GROWTH | - |
dc.title | Profilin 2 promotes migration, invasion, and stemness of HT29 human colorectal cancer stem cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chan-Wha | - |
dc.identifier.doi | 10.1080/09168451.2015.1043118 | - |
dc.identifier.scopusid | 2-s2.0-84942342409 | - |
dc.identifier.wosid | 000359843100007 | - |
dc.identifier.bibliographicCitation | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.79, no.9, pp.1438 - 1446 | - |
dc.relation.isPartOf | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.title | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.volume | 79 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1438 | - |
dc.citation.endPage | 1446 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | TUMOR-INITIATING CELLS | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | ARP2/3 COMPLEX | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordPlus | CADHERIN | - |
dc.subject.keywordPlus | CLONING | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordAuthor | Cancer stem cells (CSCs) | - |
dc.subject.keywordAuthor | Migration | - |
dc.subject.keywordAuthor | Stemness | - |
dc.subject.keywordAuthor | Invasion | - |
dc.subject.keywordAuthor | Profilin 2 | - |
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