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Profilin 2 promotes migration, invasion, and stemness of HT29 human colorectal cancer stem cells

Authors
Kim, Min-JungLee, Yoo-SunHan, Gi-YeonLee, Han-NaAhn, ChiyoungKim, Chan-Wha
Issue Date
2-9월-2015
Publisher
TAYLOR & FRANCIS LTD
Keywords
Cancer stem cells (CSCs); Migration; Stemness; Invasion; Profilin 2
Citation
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.79, no.9, pp.1438 - 1446
Indexed
SCIE
SCOPUS
Journal Title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume
79
Number
9
Start Page
1438
End Page
1446
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/92509
DOI
10.1080/09168451.2015.1043118
ISSN
0916-8451
Abstract
We investigated the role of profilin 2 in the stemness, migration, and invasion of HT29 cancer stem cells (CSCs). Increased and decreased levels of profilin 2 significantly enhanced and suppressed the self-renewal, migration, and invasion ability of HT29 CSCs, respectively. Moreover, profilin 2 directly regulated the expression of stemness markers (CD133, SOX2, and beta-catenin) and epithelial mesenchymal transition (EMT) markers (E-cadherin and snail). CD133 and beta-catenin were up-regulated by overexpression of profilin 2 and down-regulated by depletion of profilin 2. SOX2 was decreased by profilin 2 depletion. E-cadherin was not influenced by profilin 2- overexpression but increased by profilin 2- knockdown. The expression of snail was suppressed by profilin 2- knockdown. We speculated that stemness and the EMT are closely linked through profilin 2-related pathways. Therefore, this study indicates that profilin 2 affects the metastatic potential and stemness of colorectal CSCs by regulating EMT- and stemness-related proteins.
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