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Continuous flow reactions in water for the synthesis of propargylamines via a metal-free decarboxylative coupling reaction
- Authors
- Jung, Bongkyun; Park, Kyungho; Song, Kwang Ho; Lee, Sunwoo
- Issue Date
- 5-8월-2015
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Flow reaction; Decarboxylative coupling; Propargylamine; Metal-free; Propiolic acid
- Citation
- TETRAHEDRON LETTERS, v.56, no.32, pp.4697 - 4700
- Indexed
- SCIE
SCOPUS
- Journal Title
- TETRAHEDRON LETTERS
- Volume
- 56
- Number
- 32
- Start Page
- 4697
- End Page
- 4700
- ISSN
- 0040-4039
- Abstract
- A range of propargylamines was synthesized via the metal-free decarboxylative coupling of alkynyl carboxylic acids with amines and paraformaldehyde in water, using a continuous flow reaction system. Aryl- and alkyl-substituted propiolic acids were found to react with secondary amines in the presence of paraformaldehyde, at 140 degrees C in water to give the desired propargylamines in good yield. (C) 2015 Elsevier Ltd. All rights reserved.
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