Interleukin-18 promoter-607 C/A and-137 G/C polymorphisms and susceptibility to type 1 diabetes: A meta-analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Kim, Jae-Hoon | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-04T13:56:53Z | - |
dc.date.available | 2021-09-04T13:56:53Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-08 | - |
dc.identifier.issn | 0198-8859 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/92910 | - |
dc.description.abstract | Objective: The aim of this study was to determine whether the functional interleukin-18 (IL-18) promoter -607 C/A (rs1946518) and -137 G/C (rs187238) polymorphisms are associated with susceptibility to type 1 diabetes (TID). Methods: A meta-analysis was conducted to assess the associations between the IL-18 -607 C/A and -137 G/C polymorphisms and T1D in overall and by ethnic group. Results: A total of 6075 cases and 5744 controls from ten studies were considered in this meta-analysis. In all study subjects, the meta-analysis showed no association between T1D and the IL-18 -607 C allele (OR = 1.083, 95% CI = 0.930-1.260, p = 0.307). However, stratification by ethnicity indicated an association between the IL-18 -607 C allele and T1D in Asians (OR = 1.506, 95% CI = 1.172-1.936, p = 0.001), but not in Europeans (OR = 0.988, 95% CI = 0.808-1.209, p = 0.907). Analysis using recessive and dominant models and homozygote contrast showed the same -607 C allele pattern in Asians and Europeans. Meta-analysis of the IL-18 -137 G/C polymorphism showed no association between T1D and the IL-18 -137 G allele in all study subjects (OR = 1.066, 95% CI = 0.926-1.2289, p = 0.375). Stratification by ethnicity indicated no association between the IL-18 -137 G allele and T1D in Europeans and Asians (OR = 1.021, 95% CI = 0.961-1.085, p = 0.504; OR = 0.851, 95% CI = 0.5821-1.245, p = 0.406). Conclusions: Our meta-analysis demonstrates that the IL-18 -607 C/A polymorphism may be associated with susceptibility to T1D in Asians, but not in Europeans. (C) 2015 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | GENE POLYMORPHISMS | - |
dc.subject | IL-18 PROMOTER | - |
dc.subject | ASSOCIATION | - |
dc.subject | MELLITUS | - |
dc.subject | DISEASE | - |
dc.subject | POPULATION | - |
dc.subject | EXPRESSION | - |
dc.subject | CHILDREN | - |
dc.subject | ONSET | - |
dc.title | Interleukin-18 promoter-607 C/A and-137 G/C polymorphisms and susceptibility to type 1 diabetes: A meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1016/j.humimm.2015.06.012 | - |
dc.identifier.scopusid | 2-s2.0-84953368688 | - |
dc.identifier.wosid | 000363001100002 | - |
dc.identifier.bibliographicCitation | HUMAN IMMUNOLOGY, v.76, no.8, pp.537 - 545 | - |
dc.relation.isPartOf | HUMAN IMMUNOLOGY | - |
dc.citation.title | HUMAN IMMUNOLOGY | - |
dc.citation.volume | 76 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 537 | - |
dc.citation.endPage | 545 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | IL-18 PROMOTER | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | ONSET | - |
dc.subject.keywordAuthor | Interleukin-18 | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Type 1 diabetes | - |
dc.subject.keywordAuthor | Meta-analysis | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.