Interleukin-18 promoter-607 C/A and-137 G/C polymorphisms and susceptibility to type 1 diabetes: A meta-analysis
- Authors
- Lee, Young Ho; Kim, Jae-Hoon; Song, Gwan Gyu
- Issue Date
- 8월-2015
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Interleukin-18; Polymorphism; Type 1 diabetes; Meta-analysis
- Citation
- HUMAN IMMUNOLOGY, v.76, no.8, pp.537 - 545
- Indexed
- SCIE
SCOPUS
- Journal Title
- HUMAN IMMUNOLOGY
- Volume
- 76
- Number
- 8
- Start Page
- 537
- End Page
- 545
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/92910
- DOI
- 10.1016/j.humimm.2015.06.012
- ISSN
- 0198-8859
- Abstract
- Objective: The aim of this study was to determine whether the functional interleukin-18 (IL-18) promoter -607 C/A (rs1946518) and -137 G/C (rs187238) polymorphisms are associated with susceptibility to type 1 diabetes (TID). Methods: A meta-analysis was conducted to assess the associations between the IL-18 -607 C/A and -137 G/C polymorphisms and T1D in overall and by ethnic group. Results: A total of 6075 cases and 5744 controls from ten studies were considered in this meta-analysis. In all study subjects, the meta-analysis showed no association between T1D and the IL-18 -607 C allele (OR = 1.083, 95% CI = 0.930-1.260, p = 0.307). However, stratification by ethnicity indicated an association between the IL-18 -607 C allele and T1D in Asians (OR = 1.506, 95% CI = 1.172-1.936, p = 0.001), but not in Europeans (OR = 0.988, 95% CI = 0.808-1.209, p = 0.907). Analysis using recessive and dominant models and homozygote contrast showed the same -607 C allele pattern in Asians and Europeans. Meta-analysis of the IL-18 -137 G/C polymorphism showed no association between T1D and the IL-18 -137 G allele in all study subjects (OR = 1.066, 95% CI = 0.926-1.2289, p = 0.375). Stratification by ethnicity indicated no association between the IL-18 -137 G allele and T1D in Europeans and Asians (OR = 1.021, 95% CI = 0.961-1.085, p = 0.504; OR = 0.851, 95% CI = 0.5821-1.245, p = 0.406). Conclusions: Our meta-analysis demonstrates that the IL-18 -607 C/A polymorphism may be associated with susceptibility to T1D in Asians, but not in Europeans. (C) 2015 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
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